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Contributor Information

  • Name Caroline Murphy ; Richard O'Kennedy
  • Institute Dublin City University

Tool Details

  • Tool name: Anti-cyanotoxin (MC-LR) scAb
  • Alternate names: MC-LR, Anti-Microcystin-LR (R66S) scAb
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Recombinant
  • Conjugate: Unconjugated
  • Host: Mouse
  • Application: ELISA ; WB
  • Description: Microcystins are cyclic heptapeptides implicated in the impairment of liver function in various animals. They have two variable amino acid residues; in the case of the cyanotoxin MC-LR the variable amino acids are Leucine (L) and Arginine (R). Microcystin-LR is the most commonly found cyanotoxin and inhibits protein phosphatase type 1 and type 2A (PP1 and PP2A) activities in the cytoplasm of liver cells, leading to hepatocytic necrosis and haemorrhaging. Chronic exposure to microcystin is a worrying phenomenon as microcystin over an extended period of time can cause cancer through the inhibition of protein phosphatases PP1 and PP2A.
  • Immunogen: Microcystin-LR
  • Immunogen UniProt ID: TBC
  • Research area: Plant Science

  • For Research Use Only

Target Details

  • Target: Microcystin-LR
  • Target background: Microcystins are cyclic heptapeptides implicated in the impairment of liver function in various animals. They have two variable amino acid residues; in the case of the cyanotoxin MC-LR the variable amino acids are Leucine (L) and Arginine (R). Microcystin-LR is the most commonly found cyanotoxin and inhibits protein phosphatase type 1 and type 2A (PP1 and PP2A) activities in the cytoplasm of liver cells, leading to hepatocytic necrosis and haemorrhaging. Chronic exposure to microcystin is a worrying phenomenon as microcystin over an extended period of time can cause cancer through the inhibition of protein phosphatases PP1 and PP2A.

Application Details

  • Application: ELISA ; WB

Handling

  • Format: Liquid
  • Storage conditions: Store at -20°C frozen (best practice). Avoid repeated freeze/thaw cycles. Stable at room temperature in the presence of 20% (v/v) glycerol.
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Murphy et al. 2018. J Immunol Methods. 463:127-133. PMID: 30321550.