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Contributor Information

  • Name Walter Bodmer
  • Institute University of Oxford

Tool Details

  • Tool name: Anti-Microglobulin Beta2 [BBM.1]
  • Clone: BBM.1
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: ELISA ; FACS ; IHC ; IP ; Fn
  • Strain: Balb/c
  • Description: BBM.1 binds significantly with fibroblasts and lymphocytes from humans and primates and can be used for the detection of Beta2-microglobulin in myeloma and other conditions (serum assay kits etc.). BBM.1 binds equivalently to free and HLA-associated Beta2-microglobulin and may be used for detection in myeloma and other conditions (e.g. within serum assay kits).
  • Immunogen: Molt 4, a human T cell line.
  • Isotype: IgG2b
  • Research area: Cancer; Tissue-specific biology
  • Myeloma used: P3X63Ag8

  • For Research Use Only

Target Details

  • Target: Microglobulin Beta 2
  • Target background: Beta2-microglobulin associates with human leucocyte antigens (HLAs).

Application Details

  • Application: ELISA ; FACS ; IHC ; IP ; Fn

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Novoselov et al. 2012. Virus Res. 166(1-2):87-96. PMID: 22445689.
  • •  Isolation of primitive endoderm, mesoderm, vascular endothelial and trophoblast progenitors from human pluripotent stem cells.
  • •  A single amino acid substitution controls DAF-dependent phenotype of echovirus 11 in rhabdomyosarcoma cells.
  • •  Josson et al. 2011. Cancer Res. 71(7):2600-10. PMID: 21427356.
  • •  ?2-microglobulin induces epithelial to mesenchymal transition and confers cancer lethality and bone metastasis in human cancer cells.
  • •  Du et al. 2009. J Mol Recognit. 22(6):465-73. PMID: 19582797.
  • •  Parham et al. 1983. J Biol Chem. 258(10):6179-86. PMID: 6189821.
  • •  Arginine 45 is a major part of the antigenic determinant of human beta 2-microglobulin recognized by mouse monoclonal antibody BBM.1.
  • •  Brodsky et al. 1979. Immunol Rev. 47:3-61. PMID: 95015.
  • •  Brodsky et al. 1979. Eur J Immunol. 9(7):536-45. PMID: 91522.
  • •  Characterization of a monoclonal anti-beta 2-microglobulin antibody and its use in the genetic and biochemical analysis of major histocompatibility antigens.
  • •  Monoclonal antibodies for analysis of the HLA system.