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Contributor Information

  • Name Rick Wood
  • Institute Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details

  • Tool name: Anti-XPA [5A2]
  • Clone: 5A2
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: 40 kDa
  • Application: ELISA ; WB
  • Strain: Balb/c
  • Description: XPA binds to the Replication Protein A (RPA) and is a core component of the nucleotide excision repair pathway. XPA is involved in one of the complementation groups of the heritable condition Xeroderma pigmentosum, where defects in nucleotide excision repair result in increased susceptibility to mutagens including UV.
  • Immunogen: HIS-tagged recombinant human XPA protein.
  • Isotype: IgG1
  • Research area: Genetics
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: XPA
  • Target molecular weight: 40 kDa
  • Target background: XPA binds to the Replication Protein A (RPA) and is a core component of the nucleotide excision repair pathway. XPA is involved in one of the complementation groups of the heritable condition Xeroderma pigmentosum, where defects in nucleotide excision repair result in increased susceptibility to mutagens including UV.

Application Details

  • Application: ELISA ; WB

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Wei et al. 2005. Cancer Epidemiol Biomarkers Prev. 14(8):1961-6. PMID: 16103444.
  • •  Expression of nucleotide excision repair proteins in lymphocytes as a marker of susceptibility to squamous cell carcinomas of the head and neck.
  • •  Welsh et al. 2004. Int J Cancer. 110(3):352-61. PMID: 15095299.
  • •  Reduced levels of XPA, ERCC1 and XPF DNA repair proteins in testis tumor cell lines.
  • •  Kberle et al. 1999. Curr Biol. 9(5):273-6. PMID: 10074455.
  • •  Defective repair of cisplatin-induced DNA damage caused by reduced XPA protein in testicular germ cell tumours.