ANTIBODIES
Contributor Information
- Name Ayham Alnabulsi
- Institute Vertebrate Antibodies Limited
Tool Details
- Tool name: Anti-Cytochrome P450 3A4 [F24 P2 B10]
- Clone: F24P2B10
- Tool type: Antibodies
- Tool sub-type: Primary antibody
- Class: Monoclonal
- Conjugate: Unconjugated
- Reactivity: Human
- Host: Mouse
- Application: ELISA ; IHC ; WB
- Strain: Balb/c
- Description: Cytochrome P450 3A4 (CYP3A4) encodes a member of the cytochrome P450 superfamily of enzymes that are a group of heme-thiolate monooxygenases. Cytochromes P450 catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP3A4 expressed mainly in the liver and intestine oxidizes xebiotics that are then removed from the body.
- Immunogen: Ovalbumin-conjugated synthetic peptide ESRDGTVSGA
- Isotype: IgG1 kappa
- Research area: Cancer; Tissue-specific biology; Cell signaling and signal transduction; Metabolism
- Myeloma used: P3X63Ag8.653
- For Research Use Only
Target Details
- Target: CYP3A4 & CYP3A5 Cytochrome P450 3A4 (EC 1.14.13.67) (Quinine 3-monooxigenase)
- Target background: Cytochrome P450 3A4 (CYP3A4) encodes a member of the cytochrome P450 superfamily of enzymes that are a group of heme-thiolate monooxygenases. Cytochromes P450 catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP3A4 expressed mainly in the liver and intestine oxidizes xebiotics that are then removed from the body.
Application Details
- Application: ELISA ; IHC ; WB
Handling
- Format: Liquid
- Concentration: 0.9-1.1 mg/ml
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15Ă°C to -25Ă°C
- Shipping conditions: Shipping at 4Ă°C
Documentation
Related Tools
References
- • Murray et al. 2010. Histopathology. 57(2):202-11. PMID: 20716162.
- • Profiling the expression of cytochrome P450 in breast cancer.
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