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Contributor Information

  • Name J. Habeshaw
  • Institute Queen Mary University of London

Tool Details

  • Tool name: Anti-CD45R [351C5]
  • Alternate names: Protein Tyrosine Phosphatase; Receptor Type C; CD45 Antigen; CD45; L-CA; T2; Protein Tyrosine Phosphatase; Receptor Type; C Polypeptide; T2 Leukocyte Common Antigen; T2 Glycoprotein; EC 3.1.3.48; GP18; CD45R; B22; LCA; LY5
  • Clone: 351C5
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: FACS ; IHC ; IF ; IP ; WB
  • Description: 351C5 may be used in the typing of leukaemias and lymphomas and in studies of Fn subsets of B and T cells.
  • Immunogen: Raji cells
  • Isotype: IgM
  • Research area: Cancer; Cell biology; Cell signaling and signal transduction; Immunology; Stem cell biology

  • For Research Use Only

Target Details

  • Target: Protein tyrosine phosphatase, receptor type, C (PTPRC, CD45R)
  • Target background: PTPRC (CD45) is a transmembrane tyrosine phosphatase that is present on all leukocytes. PTPRC regulates the threshold of T cell antigen receptor (TCR) signaling through dephosphorylation of protein tyrosine kinases (e.g. Lck and Fyn). CD45R and CD45RO are two of multiple PTPRC isoforms generated by alternative splicing. CD45R is found on B lymphocyte and T lymphocyte subsets. CD45RO is present on 50% of T cells, most granulocytes and monocytes and most mature T cell tumours.

Application Details

  • Application: FACS ; IHC ; IF ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Leitenberg et al. 1996. J Exp Med. 183(1):249-59. PMID: 8551228.
  • •  The extracellular domain of CD45 controls association with the CD4-T cell receptor complex and the response to antigen-specific stimulation.
  • •  Trowbridge et al. 1994. Annu Rev Immunol. 12:85-116. PMID: 8011300.
  • •  CD45: an emerging role as a protein tyrosine phosphatase required for lymphocyte activation and development.
  • •  Murray et al. 1985. Clin Exp Immunol. 59(2):315-26. PMID: 3872187.
  • •  Two monoclonal antibodies raised against a Burkitt lymphoma cell line recognise different cell types within lymphoid follicles.