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Contributor Information

  • Name Mike Horton
  • Institute Queen Mary University of London
  • Primary citation Horton et al. 1985. Cancer Res. 45(11 Pt 2):5663-9. PMID: 4053038.

Tool Details

  • Tool name: Anti-Integrin aVb3 [23C6]
  • Clone: 23C6
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: 125/124 kDa, 150 kDa
  • Application: FACS ; IHC ; IP ; Fn
  • Strain: Balb/c
  • Description: 23C6 reacts with the alpha V/beta 3 integrin (CD51/CD61). 23C6 may be useful for bone resorption modulation, osteoclast identification, receptor purification, malignant melanoma identification and treatment.
  • Immunogen: A cell suspension containing osteoclasts from osteoclastomas.
  • Isotype: IgG1
  • Research area: Cell biology; Cancer; Tissue-specific biology
  • Myeloma used: P3X63Ag8.653

  • For Research Use Only

Target Details

  • Target: Integrin alpha V B3 (CD51/61; Osteoclast Fn Antigen)
  • Target molecular weight: 125/124 kDa, 150 kDa
  • Target background: Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha V associates with integrin beta3 to form the osteoclast Fn antigen (vitronectin receptor). Integrin alpha V is found in osteoclasts, placenta, melanoma cell lines and some epithelial cell lines. Expression of integrin alpha V increases with melanoma progression.

Application Details

  • Application: FACS ; IHC ; IP ; Fn

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Chetty et al. 2010. Int J Cancer. 127(5):1081-95. PMID: 20027628.
  • •  Martino et al. 2009. Biomaterials. 30(6):1089-97. PMID: 19027948.
  • •  Zhou et al. 2006. J Exp Med. 203(4):1067-80. PMID: 16606672.
  • •  Marshall et al. 1995. J Cell Sci. 108 ( Pt 3):1227-38. PMID: 7542669.
  • •  Horton et al. 1985. Cancer Res. 45(11 Pt 2):5663-9. PMID: 4053038.