SMALL MOLECULES

Contributor Information
- Name Christof Grewer
- Institute Binghamton University
Tool Details
- Tool name: ASCT2 Inhibitor
- Alternate names: L-cis hydroxyproline biphenyl ester (Lc-BPE)
- Tool type: Small molecules
- Tool sub-type: Inhibitor
- Purpose: Inhibitor
- Application: molecular docking, electrophysiology, transport assays in proteoliposomes and cryo-EM structure determination of ASCT2
- Description: Lc-BPE is the highest affinity novel chemical tool for characterizing the role of Alanine-Serine-Cysteine Transporter 2 (ASCT2), a sodium-dependent transporter in a variety of tissues, in cancer and other diseases from this study. This ASCT2 inhibitor additionally provides insights into design for future clinically relevant compounds. Lc-BPW is the first inhibitor of ASCTs with sub-M affinity (Garibsingh et al., 2020).
- Research area: DNA Damage and Repair; Epigenetics & Nuclear Signalling
- Selectivity: Stereoselective
- IC50: 10ÂľM
- For Research Use Only
Related Tools
References
- • doi: https://doi.org/10.1101/2020.05.29.124305