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Contributor Information

  • Name Abhay Satoskar
  • Institute Ohio State University

Tool Details

  • Tool name: CXCR3-GFP knock-in mouse
  • Tool type: Experimental models
  • Tool sub-type: Mouse
  • Disease: Allergic responses; Infectious and autoimmune disease; Angiogenesis; inflammation; Tumor growth
  • Model: Knock-In
  • Description: Chemokines are typically small, secreted molecules that participate in leukocyte trafficking, recruitment, and activation. They also play roles in normal and pathological processes including allergic responses, infectious and autoimmune disease, angiogenesis, inflammation, and tumor growth and metastasis. CXC chemokine receptor 3 (CXCR3) is expressed by natural killer cells, neutrophils, T cells and plasmacytoid dendritic cells. CXCR3 ligands are produced in extremely high levels during inflammation and infection, but they may also be possible targets for development of therapeutics for autoimmune and cancer diseases. There is a significant need for animal models to track and investigate CXCR3 expressing cells for diagnostic and therapeutic tool development.
  • Research area: Cancer; Immunology

  • For Research Use Only

Target Details

  • Target: CXCR3

Application Details

Handling

  • Shipping conditions: Embryo/Spermatoza- Dry Ice

Documentation

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References

  • •  Cohen et al. 2013. PLoS Pathog. 9(10):e1003706. PMID: 24130498.
  • •  Oghumu et al. 2013. J Immunol. 190(5):2229-40. PMID: 23338236.