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Contributor Information

  • Name Mikhail Plentnikov
  • Institute Johns Hopkins University

Tool Details

  • Tool name: Homozygous Mutant DISC1 (1302) mouse
  • Tool type: Experimental models
  • Tool sub-type: Mouse
  • Disease: Schizophrenia and psychiatric illnesses
  • Model: Mutant
  • Model description:
  • Genetic background and cross history: C57BL6/J
  • Zygosity: Homozygous
  • Description: This homozygous mouse strain (1302) carries mutant hDISC1 without gross developmental defects. In this strain, the expression of mutant hDISC1 is restricted to forebrain regions using TET-off system under the control of CAMKII. In addition, the expression can be suppressed by feeding the mice with doxycycline (DOX). These transgenic animals allow selective control of mutant hDISC1 expression in forebrain neurons and, herein provide a valuable research tool to study pathogenesis of schizophrenia and to conduct experimental therapeutics for the disease. This line is on a C57BL6/J background.
  • Research area: Neurobiology; Drug development

  • For Research Use Only

Target Details

  • Target: DISC1

Application Details

Handling

Documentation

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References

  • •  Pogorelov et al. 2012. Neuropharmacology. 62(3):1242-51. PMID: 21315744.
  • •  Abazyan et al. 2010. Biol Psychiatry. 68(12):1172-81. PMID: 21130225.