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Contributor Information

  • Name Devanand Sarkar
  • Institute Virginia Commonwealth University

Tool Details

  • Tool name: AEG-1?HEP mouse
  • Tool type: Experimental models
  • Tool sub-type: Mouse
  • Disease: Hepatocellular Carcinogenesis; Chronic Inflammation
  • Model: Conditional KO
  • Conditional: Yes
  • Conditional description: Conditional AEG-1ΔHEP knockout after single i.p. injection of 10Âľg/gm body weight of N-nitrosodiethylamine (DEN) given at 14 days of age followed by 0.05% phenobarbital daily in drinking water.
  • Genetic background and cross history: Floxed AEG-1 mice (AEG-1fl/fl) in C57BL/6 background were crossed with Alb/Cre (B6.Cg-Tg(Alb-cre)21Mgn/J)
  • Phenotype: Hepatocellular Carcinogenesis
  • Zygosity: unknown
  • Strain: C57BL/6
  • Description: Mouse model with conditional AEG-1 knockout in hepatocytes
  • Research area: Cancer; Cell signaling and signal transduction; Genetics; Immunology
  • Production details: Floxed AEG-1 mice (AEG-1fl/fl) in C57BL/6 background were crossed with Alb/Cre (B6.Cg-Tg(Alb-cre)21Mgn/J)

  • For Research Use Only

Target Details

  • Target: Astrocyte Elevated Gene-1

Application Details

Handling

  • Shipping conditions: Embryo/Spermatoza- Dry Ice

Documentation

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References

  • •  Robertson et al. 2018. Cancer Res. 78(22):6436-6446. PMID: 30181179.
  • •  Astrocyte Elevated Gene-1 Regulates Macrophage Activation in Hepatocellular Carcinogenesis.