EXPERIMENTAL MODELS
Contributor Information
- Name Fiona Watt
- Institute Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Tool Details
- Tool name: Inva2b1 Mouse
- Tool type: Experimental models
- Tool sub-type: Mouse
- Disease: Psoriasis
- Conditional: Yes
- Conditional description: Conditional expression of integrins under involucrin promoter giving tissue-specific suprabasal epidermal expression.
- Genetic background and cross history: Involucrin - integrin transgene expression constructs were injected into fertilized oocytes from F1 hybrid CBAxC57Bl/6 mice. Transgene-positive mice were back-crossed to generate individual founder lines. alpha2 founder line was crossed with beta1 founder line to generate alpha2beta1 line.
- Phenotype: Skin abnormalities (abnormal keratinocyte differentiation, hyperproliferation, inflammatory lesions)
- Zygosity: Heterozygous
- Strain:
- Description: Disease model for psoriasis; in vivo study of human alpha2 and beta1 integrin transgene expression in skin.
- Research area: Cell biology; Genetics
- Production details: Involucrin - integrin transgene expression constructs were injected into fertilized oocytes from F1 hybrid CBAxC57Bl/6 mice. Transgene-positive mice were back-crossed to generate individual founder lines. alpha2 founder line was crossed with beta1 founder line to generate alpha2beta1 line.
- Additional notes: Mice present phenotype very similar to human psoriasis disease.
- For Research Use Only
Target Details
- Target: Alpha2 intergrin, beta1 integrin
Application Details
Handling
- Shipping conditions: Embryo/Spermatoza- Dry Ice
Documentation
Related Tools
References
- • Carroll et al. 1995. Cell. 83(6):957-68. PMID: 8521519.
- • Suprabasal integrin expression in the epidermis of transgenic mice results in developmental defects and a phenotype resembling psoriasis.
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