CELL LINES
Contributor Information
- Name Stefan Erkeland
- Institute Erasmus Medical Center
Tool Details
- Tool name: MLL-AF9-miR-139 knock out cell line
- Alternate names: miR-139
- Tool type: Cell Lines
- Parental cell line: Lineage negative bone marrow cells isolated from miR139 KO mice
- Organism: Mouse
- Donor: Lineage negative bone marrow cells were isolated from miR139 KO mice and transduced with MLL-AF9.
- Tissue: Bone Marrow
- Cancer type: Blood cancer
- Disease: Cancer
- Growth properties: Enhanced Proliferation
- Model: Cancer Model
- Conditional: No
- Description: MIR-139 is a critical tumor surpressor in AML
- Research area: Cancer
- Production details: Lineage negative bone marrow cells were isolated from miR139 KO mice and transduced with MLL-AF9.
- For Research Use Only
Target Details
- Target: MIR139
Application Details
Handling
- Growth medium: As published in Stavast, C.J., van Zuijen, I., Karkoulia, E. et al. The tumor suppressor MIR139 is silenced by POLR2M to promote AML oncogenesis. Leukemia 36, 687ÄË?Â?Â700 (2022). https://doi.org/10.1038/s41375-021-01461-5
Documentation
References
- • Stavast et al. 2022. Leukemia. 36(3):687-700. PMID: 34741119.
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