CELL LINES
Contributor Information
- Name Bernhard Singer
- Institute LeukoCom
Tool Details
- Tool name: HEK293-CEACAM1-Fc cell line
- Alternate names: Carcinoembryonic antigen-related cell adhesion molecule 1, CD66a, Cluster of Differentiation 66a
- Tool type: Cell Lines
- Tool sub-type: Continuous
- Parental cell line: HEK293
- Organism: Human
- Tissue: Kidney
- Growth properties: Adherent
- Model: Transgenic
- Conditional: No
- Description: CEACAM-1, also known as CD66a, is an immunoglobulin superfamily protein that is expressed on neutrophils, activated NK cells, bile duct and colonic epithelial cells, and endothelial cells. CEACAM-1 is heavily glycosylated and carries high mannose residues and (sialyl) Lewis-x. It is expressed as at least three soluble and seven transmembrane isoforms, with variations occurring in both the ECD and cytoplasmic region. It engages in homotypic adhesion and heterotypic adhesion with CEACAM-3/CD66d and CEACAM-6/CD66c. On neutrophils, CEACAM-1 additionally binds to dendritic cell DC-SIGN via its Lewis-x moiety, inducing dendritic cell maturation and a subsequent Th1-type response
- Research area: Cancer; Cell biology; Immunology
- Production details: Overexpression of human CEACAM1-Fc Chimera Protein
- For Research Use Only
Target Details
- Target: CEACAM1
Application Details
Handling
- Format: Frozen
- Growth medium: DMEM + 10% FBS
- Shipping conditions: Dry ice
Documentation
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