CELL LINES
Contributor Information
- Name H. Grossman ; Anita Sabichi
- Institute University of Michigan
Tool Details
- Tool name: UM-UC-11 (Human transitional cell carcinoma of the bladder) cell line
- Alternate names: UM-UC-11
- Tool type: Cell Lines
- Organism: Human
- Tissue: Bladder
- Cancer type: Genitourinary cancer
- Disease: Cancer
- Growth properties: Adherent
- Model: Cancer Model
- Conditional: Yes
- Description: UM-UC-11 are a human transitional cell carcinoma of the bladder. These cells were assessed for their susceptibility to adenoviral mediated gene delivery, tumor growth in nude mice and differences in genetic alterations. Tumorigenicity studies in nude mice revealed the UM-UC-11 do not produce tumors, even after extended observation. UM-UC-11 demonstrated efficient gene transduction via an adenoviral vector when compared to several of the other cells evaluated. UM-UC-11 also showed intermediate levels of Coxsackie adenovirus receptor (CAR) expression of the cells tested. These assays allowed for characterization of some of the most important features in each of the respective lines in an effort to more accurately establish commonly observed phenomena across cells of the same type of neoplasm. Tnao38 cells have been shown to be exceed protein expression of both Sf9 and High Five cell lines (Hashimoto et al.,2010).
- Research area: Cancer
- For Research Use Only
Target Details
Application Details
Handling
- Format: Frozen
- Growth medium: Cells were grown in Dulbecco's modified Eagle's medium (DMEM) containing 10% heat inactivated Fetal Bovine Serum (FBS) and were supplemented with 1% penicillin and streptomycin at 37?°C in 5% CO2 environment.
- Shipping conditions: Dry ice
Documentation
Related Tools
References
- • Sabichi et al. 2006. J Urol. 175(3 Pt 1):1133-7. PMID: 16469639.
- • Grossman et al. 1984. J Urol. 132(4):834-7. PMID: 6471236.
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