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Contributor Information

  • Name Anne Lykkesfeldt
  • Institute Danish Cancer Society, Denmark
  • Primary citation Kirkegaard et al. 2014. Cancer Lett. 344(1):90-100. PMID: 24513268.

Tool Details

  • Tool name: T47D/S5 Cell Line
  • Tool type: Cell Lines
  • Tool sub-type: Continuous
  • Parental cell line: T47D
  • Organism: Human
  • Tissue: Breast
  • Cancer type: Breast cancer
  • Disease: Cancer
  • Model: Tumour line
  • Application: Determining molecular mechanisms around fulvestrant resistance
  • Description: The T47D/S5 cell line is a control cell line for the fulvestrant (Faslodex) resistant T47D/182R-1 and T47D/182R-2 cell lines. T47D/S5 is adherent and the morphology is polygonal epithelial. The cell passage number is 155 (AL3043, AL3044).

    T47D/S5 cells express oestrogen receptor alpha and progesterone receptor.

    This cell line allows the study of the mechanisms involved in fulvestrant resistant breast cancer cell growth.
  • Research area: Cancer; Drug development
  • Production details: T47D/S5 cells grows continuously in presence of 5% fetal calf serum.
  • Cellosaurus ID: CVCL_1D46

  • For Research Use Only

Target Details

  • Target: Oestrogen receptor

Application Details

  • Application: Determining molecular mechanisms around fulvestrant resistance

Handling

  • Format: Frozen
  • Passage number: Passage 155 (AL3043, AL3044)
  • Growth medium: Phenol red free RPMI 1640 + 5% FCS + glutamax + 8ug Insulin/ml
  • Temperature: 37° C
  • Atmosphere: 5% CO2
  • Shipping conditions: Dry ice

Documentation

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References

  • •  Larsen et al. 2015. PLoS One. 10(2):e0118346. PMID: 25706943.
  • •  Larsen et al. 2015. BMC Cancer. 15(1):1-15. PMID: 25885472.
  • •  Thrane et al. 2014. Oncogene. 34(32): 4199-4210. PMID: 25362855.
  • •  Kirkegaard et al. 2014. Cancer Lett. 344(1):90-100. PMID: 24513268.