ANTIBODIES
Contributor Information
- Name Tony Tiganis
- Institute Monash University
Tool Details
- Tool name: Anti-PTPN2 [RE5a]
- Alternate names: Protein Tyrosine Phosphatase Non-Receptor Type 2 Monoclonal Antibody
- Clone: RE5a
- Tool type: Antibodies
- Tool sub-type: Primary antibodies
- Class: Monoclonal
- Reactivity: Human
- Host: Mouse
- Cancer type: Breast cancer; Blood cancer
- Disease: Cancer; Autoimmune disease
- Molecular weight of the target: 45 kDa
- Application: WB, IHC
- Description: This monoclonal antibody recognizes human PTPN2 at an epitope between AA 1-317, which includes the PTPN2 catalytic domain. This region is identical between the 45 kDa and 48 kDa variants, and RE5a can detect PTPN2 at both its nuclear and cytoplasmic locations.
- Immunogen: recombinant human 45-kDa PTPN2
- Isotype: IgG3 kappa
- Research area: Cancer; Immunology; Neurobiology; Cell signaling and signal transduction
- For Research Use Only
Target Details
- Target: PTPN2
- Target alternate names: TC-PTP, PTPT, Protein Tyrosine Phosphatase Non-Receptor Type 2
- Target molecular weight: 45 kDa
- Target background: PTPN2 encodes a protein tyrosine phosphatase which has influence on T cell recruitment and function. The 48 kDa variant and is found on the cytosoic side of the ER, and the 45 kDa variant is targeted to the nucleus and cytoplasm. Targets of PTPN2 include Src family kinases, JAK kinases, and (only for the 45 kDa protein) various STAT proteins. PTPN2 is a tumor suppressor gene afflilated with triple negative breast cancer. PTPN2 also plays a role in anti-tumor immunity and T cell activation.
Application Details
- Application: WB, IHC
Handling
- Storage conditions: -20 Ă°C
- Shipping conditions: 4 Ă°C
Documentation
Related Tools
References
- • Goh PK et al. 2022. Sci Adv. 8(8):eabk3338. PMID:ĂÂ 35196085.
.svg)
.svg)
