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Contributor Information

  • Institute Netherlands Cancer Institute

Tool Details

  • Tool name: Anti-CD56 [NKI-Nbl-3]
  • Alternate names: NCAM1; Neural Cell Adhesion Molecule 1
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: ~150 kDa
  • Application: IP ; WB
  • Strain: Balb/c
  • Description: CD56, is a homophilic binding glycoprotein expressed on the surface of neurons, glia and skeletal muscle. Although CD56 is often considered a marker of neural lineage commitment due to its discovery site, CD56 expression is also found in, among others, the hematopoietic system. Here, the expression of CD56 is most stringently associated with, but certainly not limited to, natural killer cells. CD56 has been detected on other lymphoid cells, including gamma delta (Î?δ) Τ cells and activated CD8+ T cells, as well as on dendritic cells. CD56 has been implicated as having a role in cell–cell adhesion, neurite outgrowth, synaptic plasticity, and learning and memory
  • Immunogen: CHP-212 human neuroblastoma cell line
  • Isotype: IgG2
  • Research area: Cancer; Cell biology; Immunology; Neurobiology
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: CD56
  • Target molecular weight: ~150 kDa
  • Target background: CD56, is a homophilic binding glycoprotein expressed on the surface of neurons, glia and skeletal muscle. Although CD56 is often considered a marker of neural lineage commitment due to its discovery site, CD56 expression is also found in, among others, the hematopoietic system. Here, the expression of CD56 is most stringently associated with, but certainly not limited to, natural killer cells. CD56 has been detected on other lymphoid cells, including gamma delta (?d) cells and activated CD8+ T cells, as well as on dendritic cells. CD56 has been implicated as having a role in cellcell adhesion, neurite outgrowth, synaptic plasticity, and learning and memory

Application Details

  • Application: IP ; WB

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Moolenaar et al. 1990. Cancer Res. 50(4):1102-6. PMID: 2153450.