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Contributor Information

  • Name Fanxiu Zhu
  • Institute Florida State University Research Foundation

Tool Details

  • Tool name: Anti-ORF33 [ORF33]
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Other Species
  • Host: Mouse
  • Application: WB
  • Description: Kaposi's sarcoma-associated herpesvirus (KSHV) has been identified as the causative agent of Kaposi's sarcoma, the most common malignancy in HIV-infected individuals. KSHV has also been shown to be be associated with two lymphoproliferative diseases (Fu et al., 2015). This mouse monoclonal antibody for KSHV (tegument) protein open reading frame 33 (ORF 33) was generated using a bacterially produced recombinant protein as an antigen. ORF33 has been shown to be a crucial component of progeny virion production in conjunction with ORF45. ORF33 binding domain has been mapped to the highly conserved carboxyl-terminal 19 aa of ORF 45 and to USP7 binding domain according to Gillen et al., 2015. ORF33 has also been shown to interact with ORF38.
  • Immunogen: A bacterially produced recombinant ORF 33 protein was used as an antigen
  • Isotype: IgG
  • Research area: Genetics; Microbiology

  • For Research Use Only

Target Details

  • Target: Open Reading Frame 33
  • Target background: Kaposi's sarcoma-associated herpesvirus (KSHV) has been identified as the causative agent of Kaposi's sarcoma, the most common malignancy in HIV-infected individuals. KSHV has also been shown to be be associated with two lymphoproliferative diseases (Fu et al., 2015). This mouse monoclonal antibody for KSHV (tegument) protein open reading frame 33 (ORF 33) was generated using a bacterially produced recombinant protein as an antigen. ORF33 has been shown to be a crucial component of progeny virion production in conjunction with ORF45. ORF33 binding domain has been mapped to the highly conserved carboxyl-terminal 19 aa of ORF 45 and to USP7 binding domain according to Gillen et al., 2015. ORF33 has also been shown to interact with ORF38.

Application Details

  • Application: WB

Handling

  • Format: Liquid
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Wu et al. 2016. J Virol. 90(4):1741-56. PMID: 26637455.
  • •  Gillen et al. 2015. J Virol. 89(9):4918-31. PMID: 25694600.