ANTIBODIES

Contributor Information
- Name Jack A Schalken
- Institute Radboud University Medical Center (UMC)
Tool Details
- Tool name: Anti-Cadherin 6 [2B6-D8]
- Alternate names: Cadherin 6, CDH6
- Tool type: Antibodies
- Tool sub-type: Primary antibody
- Class: Monoclonal
- Conjugate: Unconjugated
- Host: Mouse
- Application: IHC
- Strain: Balb/c
- Description: From Shimazui et al Clin Cancer Res. 1998 Oct;4(10):2419-24. "In many carcinomas, E-cadherin is considered to be a prognostic marker for patient survivals, and its decreased expression is associated with metastatic disease. Among renal cell carcinomas (RCCs), however, only 20% of tumors express E-cadherin, whereas a much higher percentage express other cadherins, e.g., N-cadherin and cadherin-6. Among these cadherins expressed in RCCs, cadherin-6 has been identified as a major cadherin in the renal proximal tubules and in the tumors themselves." The inventors of this reagent found that " These results suggest that cadherin-6 is a major cadherin playing an essential role in cell-cell adhesion in E-cadherin-absent RCC."
- Immunogen: glutathione S-transferase (GST) fusion extracellular domain of human cadherin-6a
- Research area: Cell biology; Cancer
- Myeloma used: Sp2/0-Ag14
- For Research Use Only
Target Details
- Target: Cadherin-6
- Target background: From Shimazui et al Clin Cancer Res. 1998 Oct;4(10):2419-24. "In many carcinomas, E-cadherin is considered to be a prognostic marker for patient survivals, and its decreased expression is associated with metastatic disease. Among renal cell carcinomas (RCCs), however, only 20% of tumors express E-cadherin, whereas a much higher percentage express other cadherins, e.g., N-cadherin and cadherin-6. Among these cadherins expressed in RCCs, cadherin-6 has been identified as a major cadherin in the renal proximal tubules and in the tumors themselves." The inventors of this reagent found that " These results suggest that cadherin-6 is a major cadherin playing an essential role in cell-cell adhesion in E-cadherin-absent RCC."
Application Details
- Application: IHC
Handling
- Format: Liquid
- Shipping conditions: Shipping at 4ðC
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References
- • Shimazui et al. 1998. Clin Cancer Res. 4(10):2419-24. PMID: 9796973.