ANTIBODIES
Contributor Information
- Name Joost Schalkwijk
- Institute Radboud University Medical Center (UMC)
Tool Details
- Tool name: Anti-pan-late cornified envelope 3, pan-LCE3 [7]
- Alternate names: Late envelope protein 16, Small proline-rich-like epidermal differentiation complex protein 6A, Small proline-rich-like epidermal differentiation complex protein 6B
- Tool type: Antibodies
- Tool sub-type: Primary Antibody
- Class: Monoclonal
- Conjugate: Unconjugated
- Reactivity: Human
- Host: Mouse
- Application: ELISA ; IHC ; IF
- Description: The LCE3 proteins are structural components of the cornified envelope of the stratum corneum and may be involved in innate cutaneous host defence. They have been shown to posses antibacterial (gram positive and negative, aerobic and anaerobic species) properties. During inflammation they have been shown to be involved in skin repair (PMID: 28634035). Deletion of LCE3B and LCE3C proteins have been shown to be a significant risk factor in psoriasis.
- Immunogen: Late cornified envelope protein 3B
- Research area: Extracellular Matrix; Immunology
- Myeloma used: Sp2/0
- For Research Use Only
Target Details
- Target: Late cornified envelope (LCE) protein 3
- Target background: The LCE3 proteins are structural components of the cornified envelope of the stratum corneum and may be involved in innate cutaneous host defense. They ahve been shown to posses antibacterial (gram positive and negative, aerobic and anearobic speacies) properties. During inflammation they haev been shown to be involved in skin repair (PMID: 28634035). Deletion of LCE3B and LCE3C proteins has been shown to be a significant risk factor in psoriasis.
Application Details
- Application: ELISA ; IHC ; IF
Handling
- Format: Liquid
- Shipping conditions: Shipping at 4°C
Documentation
Related Tools
References
- • Niehues et al. 2016. Br J Dermatol. 174(4):795-802. PMID: 26556599.
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