ANTIBODIES

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Anti-PKD

Cat. #158062

Tool name: Anti-PKD
Tool type: Antibodies
Class: Polyclonal
Conjugate: Unconjugated
Reactivity: Tetracapsuloides bryosalmonae
Host: Rabbit
Molecular weight of the target: 31
Application: ELISA ; IHC ; WB
Description: Proliferative kidney disease (PKD), caused by the myxozoan parasite Tetracapsuloides bryosalmonae, is one of the most economically damaging diseases to trout aquaculture. T. bryosalmonae has a two-host life cycle, as other myxosporeans, cycling between freshwater bryozoan and salmonid fish species. It is characterised by a swollen kidney and spleen, bloody ascites, and pale gills, indicating the fish becomes anemic at the late stage of the disease. This parasite is allowed to cross the renal tubules wall to proliferate within the interstitial tissue of kidney, inducing a chronic lymphoid hyperplasia marked by a strong parasite-driven immunosuppressant pathogenesis and a dysregulation of T-helper subsets. Fish recovering from PKD develop protective immunity to subsequent parasite challenge, providing the impetus for vaccine development. A polyclonal antibody used to identify T. bryosalmonae antigens will be able to elicit protective immune responses for developing DNA vaccines. This is a useful diagnostic tool to identify T. bryosalmonae parasite. This antibody is potentially neutralizing providing a valuable research tool to study parasite-host interactions and vaccine development.
Immunogen: Ovalbumin-conjugated synthetic peptide.
Research area: Cell biology; Immunology

Target: Tetracapsuloides bryosalmonae parasite antigen
Target molecular weight: 31
Target background: Proliferative kidney disease (PKD), caused by the myxozoan parasite Tetracapsuloides bryosalmonae, is one of the most economically damaging diseases to trout aquaculture. T. bryosalmonae has a two-host life cycle, as other myxosporeans, cycling between freshwater bryozoan and salmonid fish species. It is characterised by a swollen kidney and spleen, bloody ascites, and pale gills, indicating the fish becomes anemic at the late stage of the disease. This parasite is allowed to cross the renal tubules wall to proliferate within the interstitial tissue of kidney, inducing a chronic lymphoid hyperplasia marked by a strong parasite-driven immunosuppressant pathogenesis and a dysregulation of T-helper subsets. Fish recovering from PKD develop protective immunity to subsequent parasite challenge, providing the impetus for vaccine development. A polyclonal antibody used to identify T. bryosalmonae antigens will be able to elicit protective immune responses for developing DNA vaccines. This is a useful diagnostic tool to identify T. bryosalmonae parasite. This antibody is potentially neutralizing providing a valuable research tool to study parasite-host interactions and vaccine development.

£ 300
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