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Contributor Information

  • Name Abdo Alnabulsi
  • Institute Vertebrate Antibodies Limited

Tool Details

  • Tool name: Anti-IgT
  • Tool type: Antibodies
  • Class: Polyclonal
  • Conjugate: Unconjugated
  • Reactivity: Grass Carp
  • Host: Rabbit
  • Molecular weight of the target: 65
  • Application: ELISA
  • Description: Teleost IgT is specialised in gut mucosal immunity. IgT is present in serum as monomers, whereas in the gut mucus it forms mainly noncovalent multimers similar in mass to IgM. In fish, IgT+ B cells have been identified in several species and constitute around 51% of all B cells in the intestinal mucosa. Consistent with the prevalent roles of IgT in gut immunity, most bacteria in the gut lumen are coated with IgT, and IgT responses to gut parasites are measurable only in the gut, whereas IgM responses are detected only in serum. This anti-IgT antibody may provide a useful tool to monitor vaccine performance in fish and will assist in the development of future vaccines. Anti-IgT antibody may provide a useful tool to monitor mucosal-based vaccine performance in fish and will assist in the development of future vaccines.
  • Immunogen: Ovalbumin-conjugated synthetic peptide. Peptide immunogen is conserved in carp species.
  • Research area: Cell biology; Immunology

  • For Research Use Only

Target Details

  • Target: Immunoglobulin T (IgT)-heavy chain
  • Target molecular weight: 65
  • Target background: Teleost IgT is specialised in gut mucosal immunity. IgT is present in serum as monomers, whereas in the gut mucus it forms mainly noncovalent multimers similar in mass to IgM. In fish, IgT+ B cells have been identified in several species and constitute around 51% of all B cells in the intestinal mucosa. Consistent with the prevalent roles of IgT in gut immunity, most bacteria in the gut lumen are coated with IgT, and IgT responses to gut parasites are measurable only in the gut, whereas IgM responses are detected only in serum. This anti-IgT antibody may provide a useful tool to monitor vaccine performance in fish and will assist in the development of future vaccines. Anti-IgT antibody may provide a useful tool to monitor mucosal-based vaccine performance in fish and will assist in the development of future vaccines.

Application Details

  • Application: ELISA

Handling

  • Format: Liquid
  • Storage buffer: Unpurified anti-serum from rabbit preserved in 0.02% Thiomersal
  • Storage conditions:
  • Shipping conditions: Shipping at 4°C

Documentation