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Contributor Information

  • Institute The University of British Columbia

Tool Details

  • Tool name: Anti-CLEC16A [7A4]
  • Alternate names: CLEC16A (also known as KIAA35)
  • Tool type: Antibodies
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Rat
  • Application: ELISA ; FACS ; IF ; WB
  • Description: Antibody against CLEC16A (specifically binds to C-terminal human peptide CLEC16A954-980: VIVNETEADSKPSKNVARSAAVETASL) CLEC16A is a cytosolic protein which is differentially expressed in human immune cells and is known to be highly expressed on B-lymphocytes, natural killer (NK) and dendritic cells. CLEC16A gene has been linked to several autoimmune diseases, including Addison's disease, diabetes melllitus, Crohn's disease, primary biliary cirrhosis, juvenile idiopathic arthritis, rheumatoid arthritis and multiple sclerosis. . CLEC16A has been shown to regulate various immune pathways including directly regulating leukocyte antigen class II pathway in antigen presenting cells, autophagy, mitophagy, and NK cell cytotoxicity.
  • Immunogen: 27-mer C-terminal human peptide (CLEC16A 954-980: VIVNETEADSKPSKNVARSAAVETASL) linked to KLH
  • Research area: Disease (not cancer); Immunology; Neurobiology

  • For Research Use Only

Target Details

  • Target: C-Type Lectin Domain Containing 16A
  • Target background: antibody against CLEC16A (specifically binds to C-terminal human peptide CLEC16A954-980: VIVNETEADSKPSKNVARSAAVETASL) CLEC16A is a cytosolic protein which is differentially expressed in human immune cells and is known to be highly expressed on B-lymphocytes, natural killer (NK) and dendritic cells. CLEC16A gene has been linked to several autoimmune diseases, including Addison's disease, diabetes melllitus, Crohn's disease, primary biliary cirrhosis, juvenile idiopathic arthritis, rheumatoid arthritis and multiple sclerosis. . CLEC16A has been shown to regulate various immune pathways including directly regulating leukocyte antigen class II pathway in antigen presenting cells, autophagy, mitophagy, and NK cell cytotoxicity.

Application Details

  • Application: ELISA ; FACS ; IF ; WB

Handling

  • Format: Liquid
  • Storage buffer:
  • Storage conditions:
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  van Luijn et al. 2015. Brain. 138(Pt 6):1531-47. PMID: 25823473.