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Contributor Information

  • Name Marko Radic
  • Institute The University of Tennessee Health Science Center (UTHSC)

Tool Details

  • Tool name: Anti-Apoptosis (FUS/TLS) Autoantibody [LHC7.15]
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human ; Mouse
  • Host: Mouse
  • Molecular weight of the target: 65 kDa
  • Application: IF ; WB
  • Description: The TAM?/? mouse model (triple homozygous deletions of the Mer, Axl, and Tyro3 receptor tyrosine kinases) has delayed apoptotic cell clearance which causes the production of autoantibodies and autoimmune disease in these mice. The FUS/TLS monoclonal antibody is produced from a spontaneous splenic B cell hybridoma generated from the TAM?/? mouse. FUS/TLS binds DNA, RNA, and ribonucleoprotein in the nucleus and the cytoplasm of live and apoptotic cells. FUS/TLS is involved gene expression, genomic integrity and mRNA processing including pre-mRNA splicing and the export of mRNA to the cytoplasm. Mutations in this gene results in amyotrophic lateral sclerosis type 6 and liposarcoma.
  • Immunogen: FUS_HUMAN
  • Immunogen UniProt ID: FUS_HUMAN
  • Research area: Apoptosis and autophagy; Cancer

  • For Research Use Only

Target Details

  • Target: hnRNP-P2-TLS, FUS
  • Target molecular weight: 65 kDa
  • Target background: The TAM-/- mouse model (triple homozygous deletions of the Mer, Axl, and Tyro3 receptor tyrosine kinases) has delayed apoptotic cell clearance which causes the production of autoantibodies and autoimmune disease in these mice. The FUS/TLS monoclonal antibody is produced from a spontaneous splenic B cell hybridoma generated from the TAM-/- mouse. FUS/TLS binds DNA, RNA, and ribonucleoprotein in the nucleus and the cytoplasm of live and apoptotic cells. FUS/TLS is involved gene expression, genomic integrity and mRNA processing including pre-mRNA splicing and the export of mRNA to the cytoplasm. Mutations in this gene results in amyotrophic lateral sclerosis type 6 and liposarcoma.

Application Details

  • Application: IF ; WB

Handling

  • Format: Liquid
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Radic et al. 2006. J Immunol. 176(1):68-74. PMID: 16365397.