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Contributor Information

  • Name Patrick Loll
  • Institute Drexel University

Tool Details

  • Tool name: Anti-Human Ataxin-3 [4B8]
  • Alternate names: Machado-Joseph Disease (MJD) Protein 1; Spinocerebellar Ataxia Type 3
  • Tool type: Antibodies
  • Tool sub-type: Primary Antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: 42 kDa
  • Cell signalling pathway: PI3K signalling
  • Application: ELISA ; IP
  • Description: Ataxin-3 is a deubiquitinating enzyme involved in the clearance of misfolded proteins. The enzyme functions in proteasome degradation and autophagy. Mutated forms of Ataxin-3 can lead to misfolded protein aggregation which cause the neurodegenerative disorder spinocerebellar ataxia type-3 (SCA3), also known as Machado-Joseph disease.
  • Immunogen: Recombinant Human Ataxin-3
  • Immunogen UniProt ID: ATX3_HUMAN
  • Research area: Neurobiology; Biochemistry

  • For Research Use Only

Target Details

  • Target: Ataxin-3
  • Target molecular weight: 42 kDa
  • Target background: Ataxin-3 is a deubiquitinating enzyme involved in the clearance of misfolded proteins. The enzyme functions in proteasome degradation and autophagy. Mutated forms of Ataxin-3 can lead to misfolded protein aggregation which cause the neurodegenerative disorder spinocerebellar ataxia type-3 (SCA3), also known as Machado-Joseph disease.

Application Details

  • Application: ELISA ; IP

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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