ANTIBODIES

Contributor Information
- Institute Yale University
Tool Details
- Tool name: Anti-IE of b,k,r,s,v [Y17]
- Tool type: Antibodies
- Tool sub-type: Primary Antibody
- Class: Monoclonal
- Conjugate: Unconjugated
- Description: Monoclonal antibody which can inhibit T cell response to Ae:E alpha determinants. Background and Research Application This antibody is directed at a conformational or combinatorial determinant formed by certain Ae:E alpha complexes. This marker is found upon a subset of B cells as well as on non-T and non-B spleen cells. Antibody Y-17 can inhibit the response of T cells to Ae:E alpha determinants in mixed lymphocyte cultures. Furthermore, Y-17 inhibits the antigen-induced T cell proliferative response to GLPhe and pigeon cytochrome c; responses which are under dual-Ir-gene control and correlate with the expression of certain A~:E~ complexes on antigen-presenting cell surfaces.
- Immunogen: P04223
- Immunogen UniProt ID: P04223
- Isotype: IgG2b
- Research area: Immunology
- For Research Use Only
Target Details
- Target: IE
- Target background: Monoclonal antibody which can inhibit T cell response to Ae:E alpha determinants. Background and Research Application This antibody is directed at a conformational or combinatorial determinant formed by certain Ae:E alpha complexes. This marker is found upon a subset of B cells as well as on non-T and non-B spleen cells. Antibody Y-17 can inhibit the response of T cells to Ae:E alpha determinants in mixed lymphocyte cultures. Furthermore, Y-17 inhibits the antigen-induced T cell proliferative response to GLPhe and pigeon cytochrome c; responses which are under dual-Ir-gene control and correlate with the expression of certain A~:E~ complexes on antigen-presenting cell surfaces.
Application Details
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Storage buffer: PBS with 0.02% azide
- Storage conditions: Store at -20ðC frozen. Avoid repeated freeze / thaw cycles
- Shipping conditions: Shipping at 4ðC
References
- • Lerner et al. 1980. J Exp Med. 152(4):1085-101. PMID: 6158546.