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Contributor Information

  • Institute Yale University

Tool Details

  • Tool name: Anti-IE of b,k,r,s,v [Y17]
  • Tool type: Antibodies
  • Tool sub-type: Primary Antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Description: Monoclonal antibody which can inhibit T cell response to Ae:E alpha determinants. Background and Research Application This antibody is directed at a conformational or combinatorial determinant formed by certain Ae:E alpha complexes. This marker is found upon a subset of B cells as well as on non-T and non-B spleen cells. Antibody Y-17 can inhibit the response of T cells to Ae:E alpha determinants in mixed lymphocyte cultures. Furthermore, Y-17 inhibits the antigen-induced T cell proliferative response to GLPhe and pigeon cytochrome c; responses which are under dual-Ir-gene control and correlate with the expression of certain A~:E~ complexes on antigen-presenting cell surfaces.
  • Immunogen: P04223
  • Immunogen UniProt ID: P04223
  • Isotype: IgG2b
  • Research area: Immunology

  • For Research Use Only

Target Details

  • Target: IE
  • Target background: Monoclonal antibody which can inhibit T cell response to Ae:E alpha determinants. Background and Research Application This antibody is directed at a conformational or combinatorial determinant formed by certain Ae:E alpha complexes. This marker is found upon a subset of B cells as well as on non-T and non-B spleen cells. Antibody Y-17 can inhibit the response of T cells to Ae:E alpha determinants in mixed lymphocyte cultures. Furthermore, Y-17 inhibits the antigen-induced T cell proliferative response to GLPhe and pigeon cytochrome c; responses which are under dual-Ir-gene control and correlate with the expression of certain A~:E~ complexes on antigen-presenting cell surfaces.

Application Details

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: Store at -20°C frozen. Avoid repeated freeze / thaw cycles
  • Shipping conditions: Shipping at 4°C

Documentation

References

  •   Lerner et al. 1980. J Exp Med. 152(4):1085-101. PMID: 6158546.