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Contributor Information

  • Institute Yale University

Tool Details

  • Tool name: Anti-Sm [Y12]
  • Tool type: Antibodies
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Host: Mouse
  • Description: Monoclonal antibody used in quantitative radioimmuno-assays in SLE patients. Background and Research Application Sm is an autoantigen on a series of particles composed of RNA and protein. It is one of several nuclear proteins that are found commonly among U1, U2, U4/U6, and U5 small ribonucleoprotein particles (snRNPs). These snRNPs are involved in pre-mRNA splicing, and the encoded protein may also play a role in pre-mRNA splicing or snRNP structure. Sm is involved in the pathogenesis of Systemic lupus erythematosus (SLE), with antibodies to Sm being found in 20-30% of patients with SLE. This antibody can aid in the titration of autoantibody activity in the sera of SLE patients. Anti-Sm antibody can be used to help understand the role of snRNPs, particularly within disease.
  • Immunogen: P27048
  • Immunogen UniProt ID: P27048
  • Isotype: IgG3 kappa
  • Research area: Immunology

  • For Research Use Only

Target Details

  • Target: Sm
  • Target background: Monoclonal antibody used in quantitative radioimmuno-assays in SLE patients Background and Research Application Sm is an autoantigen on a series of particles composed of RNA and protein. It is one of several nuclear proteins that are found commonly among U1, U2, U4/U6, and U5 small ribonucleoprotein particles (snRNPs). These snRNPs are involved in pre-mRNA splicing, and the encoded protein may also play a role in pre-mRNA splicing or snRNP structure. Sm is involved in the pathogenesis of Systemic lupus erythematosus (SLE), with antibodies to Sm being found in 20-30% of patients with SLE. This antibody can aid in the titration of autoantibody activity in the sera of SLE patients. Anti-Sm antibody can be used to help understand the role of snRNPs, particularly within disease.

Application Details

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: 4°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Lerner et al. 1981. Proc Natl Acad Sci U S A. 78(5):2737-41. PMID: 6789322.