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Contributor Information

  • Institute Versiti Blood Research Institute

Tool Details

  • Tool name: Anti-AvW-15 (von Willebrand Factor) [MBC 122.6]
  • Alternate names: vWf
  • Tool type: Antibodies
  • Tool sub-type: Primary Antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: 250 kDa
  • Application: ELISA ; WB
  • Description: Von Willebrand factor (vWF) is a multimeric glycoprotein that functions in hemostasis as the initiator of platelet adhesion at the site of vascular injury and as the carrier of the anti-hemophilic factor, factor VIII (FVIII). Hereditary or acquired defects of VWF lead to von Willebrand disease (vWD), a bleeding diathesis of the skin and mucous membranes, causing nosebleeds, menorrhagia, and gastrointestinal bleeding.
  • Immunogen: R/A (reduced and alkylated) fragment of vWF (see notes column)
  • Research area: Immunology
  • Myeloma used: P3X63Ag8.653

  • For Research Use Only

Target Details

  • Target: von Willebrand Factor
  • Target molecular weight: 250 kDa
  • Target background: Von Willebrand factor (vWF) is a multimeric glycoprotein that functions in hemostasis as the initiator of platelet adhesion at the site of vascular injury and as the carrier of the anti-hemophilic factor, factor VIII (FVIII). Hereditary or acquired defects of VWF lead to von Willebrand disease (vWD), a bleeding diathesis of the skin and mucous membranes, causing nosebleeds, menorrhagia, and gastrointestinal bleeding.

Application Details

  • Application: ELISA ; WB

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Flood et al. 2018. Res Pract Thromb Haemost. 2(2):390-398. PMID: 30046743.
  • •  Doruelo et al. 2017. J Thromb Haemost. 15(8):1559-1566. PMID: 28544236.
  • •  Roberts et al. 2016. Blood. 127(20):2472-80. PMID: 26917779.
  • •  Flood et al. 2015. Blood. 125(14):2297-304. PMID: 25662333.
  • •  Flood et al. 2013. Clin Chem. 59(4):684-91. PMID: 23340442.
  • •  Jacobi et al. 2012. Blood. 119(19):4543-53. PMID: 22431572.
  • •  Flood et al. 2011. Blood. 117(6):e67-74. PMID: 21148813.