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Contributor Information

  • Institute Absolute Antibody; University of Oxford

Tool Details

  • Tool name: Anti-Spectrin [RG/26] rAb
  • Clone: RG/26
  • Tool type: Antibodies
  • Tool sub-type: Primary Antibody
  • Class: Recombinant
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Description: Spectrin is a cytoskeletal protein that lines the intracellular side of the plasma membrane of many cell types in pentagonal or hexagonal arrangements, forming a scaffolding and playing an important role in maintenance of plasma membrane integrity and cytoskeletal structure. In certain types of brain injury such as diffuse axonal injury, spectrin is irreversibly cleaved by the proteolytic enzyme calpain, destroying the cytosketelon. Spectrin cleavage causes the membrane to form blebs and ultimately to be degraded, usually leading to cell death.
  • Immunogen: Red cell membranes
  • Isotype: IgG2a
  • Research area: Tissue-specific biology; Neurobiology; Biochemistry

  • For Research Use Only

Target Details

  • Target: Spectrin
  • Target background: Spectrin is a cytoskeletal protein that lines the intracellular side of the plasma membrane of many cell types in pentagonal or hexagonal arrangements, forming a scaffolding and playing an important role in maintenance of plasma membrane integrity and cytoskeletal structure. In certain types of brain injury such as diffuse axonal injury, spectrin is irreversibly cleaved by the proteolytic enzyme calpain, destroying the cytosketelon. Spectrin cleavage causes the membrane to form blebs and ultimately to be degraded, usually leading to cell death.

Application Details

Handling

  • Format: Liquid
  • Shipping conditions: Shipping at 4° C

Documentation

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References

  • •  Host vascular endothelial growth factor is trophic for Plasmodium falciparum-infected red blood cells.
  • •  Impact of constant storage temperatures and multiple warming cycles on the quality of stored red blood cells.
  • •  Sachanonta et al. 2008. Asian Pac J Allergy Immunol. 26(1):37-45. PMID: 18595528.
  • •  Wagner et al. 2014. Vox Sang. 106(1):45-54. PMID: 23909508.