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Contributor Information

  • Institute Absolute Antibody; Cancer Research UK, London Research Institute: Clare Hall Laboratories

Tool Details

  • Tool name: Anti-Rad51 [Rad51 3C10] rAb
  • Clone: Rad51 3C10
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Recombinant
  • Conjugate: Unconjugated
  • Reactivity: Bovine ; Human ; Pig
  • Host: Mouse
  • Cancer type: Breast cancer
  • Description: Recombinant antibody which binds RAD51 recombinase protein, associated with DNA repair pathway. Background and Research Application RAD51 is a eukaryotic homologue of E. coli RecA, a recombinase, and a component of the homologous recombination DNA repair pathway. RAD51 forms a nucleoprotein filament (through binding RAD52 and single stranded DNA that are exposed following double strand breaks) that initiates recombination. RAD51 catalyses the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Mutations in the gene can results in breast cancer, mirror movements 2 and Fanconi anaemia. This is a recombinant version of the anti-RAD51 monoclonal antibody.
  • Immunogen: Full length recombinant human RAD51 protein
  • Immunogen UniProt ID: Q06609
  • Isotype: IgG1
  • Research area: Genetics

  • For Research Use Only

Target Details

  • Target: Rad51
  • Target background: Recombinant antibody which binds RAD51 recombinase protein, associated with DNA repair pathway. Background and Research Application RAD51 is a eukaryotic homologue of E. coli RecA, a recombinase, and a component of the homologous recombination DNA repair pathway. RAD51 forms a nucleoprotein filament (through binding RAD52 and single stranded DNA that are exposed following double strand breaks) that initiates recombination. RAD51 catalyses the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Mutations in the gene can results in breast cancer, mirror movements 2 and Fanconi anaemia. This is a recombinant version of the anti-RAD51 monoclonal antibody.

Application Details

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage conditions: Store at -20° C) frozen. Avoid repeated freeze / thaw cycles
  • Shipping conditions: Shipping at 4° C

Documentation

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References

  • •  Barlow et al. 1997. EMBO J. 16(17):5207-15. PMID: 9311981.
  • •  Distribution of the Rad51 recombinase in human and mouse spermatocytes.
  • •  Endopolyploid cells produced after severe genotoxic damage have the potential to repair DNA double strand breaks.
  • •  Ivanov et al. 2003. J Cell Sci. 116(Pt 20):4095-106. PMID: 12953071.
  • •  Masson et al. 1999. EMBO J. 18(22):6552-60. PMID: 10562567.
  • •  The meiosis-specific recombinase hDmc1 forms ring structures and interacts with hRad51.