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Contributor Information

  • Institute Absolute Antibody ; University of Oxford

Tool Details

  • Tool name: Anti-Integrin b3 [Y2/51] rAb
  • Alternate names: Integrin Subunit Beta; Integrin; Beta 3 (Platelet Glycoprotein IIIa; Antigen CD61); Platelet Membrane Glycoprotein IIIa; Antigen CD61; GPIIIa; GP3A; Platelet Glycoprotein IIIa; Integrin Beta 3; CD61 Antigen; BDPLT16; BDPLT2; CD61; GT
  • Clone: Y2/51
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Recombinant
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Cancer type: Broadly Applicable
  • Description: Recombinant antibody which can detect CD61 marker on megakaryocytes.
  • Immunogen: Phytohaemagglutin-stimulated peripheral blood cells
  • Immunogen UniProt ID: P05106
  • Isotype: IgG1
  • Research area: Cell biology; Tissue-specific biology; Cell signaling and signal transduction

  • For Research Use Only

Target Details

  • Target: Integrin ?3 (CD61; GPIIIa)
  • Target background: Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells and aberrant integrin expression has been found in many epithelial tumours. CD61/ integrin b3 is a glycoprotein found on megakaryocytes, osteoclasts, platelets and their precursors. CD61 antigen plays a role in platelet aggregation and also as a receptor for fibrinogen, fibronectin, von Willebrand factor and vitronectrin. This is a recombinant version of anti-integrin B3 monoclonal antibody, which is widely used as a marker of megakaryocytes in bone marrow trephines.

Application Details

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage conditions: Store at -20° C frozen. Avoid repeated freeze / thaw cycles
  • Shipping conditions: Shipping at 4° C

Documentation

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References

  • •  Brune et al. 2007. Eur Cell Mater. 14:78-90
  • •  Complex formation of platelet membrane glycoproteins IIb and IIIa with fibrinogen.
  • •  discussion 90-1. PMID: 18085506.
  • •  Gatter et al. 1988. Histopathology. 13(3):257-67. PMID: 3192191.
  • •  Immunological study of in vitro maturation of human megakaryocytes.
  • •  In vitro comparison of human fibroblasts from intact and ruptured ACL for use in tissue engineering.
  • •  Nachman et al. 1982. J Clin Invest. 69(2):263-9. PMID: 6460044.
  • •  The immunohistological detection of platelets, megakaryocytes and thrombi in routinely processed specimens.
  • •  Vinci et al. 1984. Br J Haematol. 56(4):589-605. PMID: 6231944.