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Contributor Information

  • Institute Netherlands Cancer Institute

Tool Details

  • Tool name: Anti-CD11a (Integrin Subunit Alpha L ) [SPVL1]
  • Alternate names: ITGAL; LFA-1A
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: 126 kDa
  • Application: FACS ; IHC ; IP
  • Strain: Balb/c
  • Description: ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signalling.
  • Immunogen: Immunization of BALB/c mice with cells of the T4+T8- cytotoxic T lymphocyte clone HG-38
  • Isotype: IgG1
  • Research area: Cell biology; Cell signaling and signal transduction
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: CD11a
  • Target molecular weight: 126 kDa
  • Target background: ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signalling.

Application Details

  • Application: FACS ; IHC ; IP

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Keizer et al. 1985. Eur J Immunol. 15(11):1142-8. PMID: 2933266.
  • •  Spits et al. 1983. Hybridoma. 2(4):423-37. PMID: 6332061.