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Anti-CD11b/CR3 (Integrin Subunit Alpha M) [BEAR1]

Cat. #154771

Tool name: Anti-CD11b/CR3 (Integrin Subunit Alpha M) [BEAR1]
Alternate names: ITGAM; Leukocyte Adhesion Receptor MO1
Tool type: Antibodies
Tool sub-type: Primary antibody
Class: Monoclonal
Conjugate: Unconjugated
Reactivity: Human
Host: Mouse
Molecular weight of the target: 160 kDa
Application: FACS ; IP
Strain: Balb/c
Description: ITGAM is one protein subunit that forms heterodimeric integrin alpha-M beta-2 (ÄÂ?MÄÂ?2) molecule, also known as macrophage-1 antigen (Mac-1) or complement receptor 3 (CR3). The second chain of ÄÂ?MÄÂ?2 is the common integrin ÄÂ?2 subunit known as CD18, and integrin ÄÂ?MÄÂ?2 thus belongs to the ÄÂ?2 subfamily (or leukocyte) integrins. ÄÂ?MÄÂ?2 is expressed on the surface of many leukocytes involved in the innate immune system, including monocytes, granulocytes, macrophages, and natural killer cells. It mediates inflammation by regulating leukocyte adhesion and migration and has been implicated in several immune processes such as phagocytosis, cell-mediated cytotoxicity, chemotaxis and cellular activation
Immunogen: The mouse was immunized with purified human monocytes
Isotype: IgG1
Research area: Cell biology; Cell signaling and signal transduction; Immunology
Myeloma used: Sp2/0-Ag14

Target: CD11b/CR3
Target molecular weight: 160 kDa
Target background: ITGAM is one protein subunit that forms heterodimeric integrin alpha-M beta-2 (aM?2) molecule, also known as macrophage-1 antigen (Mac-1) or complement receptor 3 (CR3). The second chain of aM?2 is the common integrin ?2 subunit known as CD18, and integrin aM?2 thus belongs to the ?2 subfamily (or leukocyte) integrins. aM?2 is expressed on the surface of many leukocytes involved in the innate immune system, including monocytes, granulocytes, macrophages, and natural killer cells. It mediates inflammation by regulating leukocyte adhesion and migration and has been implicated in several immune processes such as phagocytosis, cell-mediated cytotoxicity, chemotaxis and cellular activation

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