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Contributor Information

  • Name Arnoud Sonnenberg
  • Institute Netherlands Cancer Institute

Tool Details

  • Tool name: Anti-CD49F (Integrin Alpha 6) [GoH3]
  • Alternate names: ITGA6
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Dog ; Human ; Mouse
  • Host: Rat
  • Molecular weight of the target: 126 kDa
  • Application: FACS ; IHC ; IP
  • Strain: Balb/c
  • Description: The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Specific loss of this integrin chain in the intestinal epithelium, and thus of their hemidesmosomes, induces long-standing colitis and infiltrating adenocarcinomas.
  • Immunogen: 1242-1255 of the C-terminus of the Human c-erbB-2/HER-2/neu protein. This sequence is identical in Rat neu
  • Isotype: IgG2a
  • Research area: Immunology
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: CD49F
  • Target molecular weight: 126 kDa
  • Target background: The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Specific loss of this integrin chain in the intestinal epithelium, and thus of their hemidesmosomes, induces long-standing colitis and infiltrating adenocarcinomas.

Application Details

  • Application: FACS ; IHC ; IP

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Yoshino et al. 2000. Exp Anim. 49(2):97-110. PMID: 10889948.
  • •  Upgrading of flow cytometric analysis for absolute counts, cytokines and other antigenic molecules of cynomolgus monkeys (Macaca fascicularis) by using anti-human cross-reactive antibodies.
  • •  Galkowska et al. 1996. Vet Immunol Immunopathol. 53(3-4):329-34. PMID: 8969052.
  • •  Ticchioni et al. 1995. J Immunol. 154(3):1207-15. PMID: 7529794.