ANTIBODIES

Contributor Information
- Institute University of Maryland
Tool Details
- Tool name: Anti-Omentin [3G1B3]
- Alternate names: Intelectin-1, ITLN1, hIntL-1
- Tool type: Antibodies
- Class: Monoclonal
- Conjugate: Unconjugated
- Reactivity: Human ; Mouse ; Rat
- Host: Mouse
- Molecular weight of the target: 120 kDa (trimer), 37 kDa (monomer)
- Application: IP ; WB
- Description: Monoclonal antibody which detects omentin, linked to diabetes. Background and Research Application: Omentin (human intelectin-1) is a secreted glycoprotein involved in the innate immune system as well as enhancing insulin-stimulated glucose uptake. Highly expressed in small intestine and adipose tissue and present at lower levels in testis, heart, pancreas, colon and skeletal muscle, intelectin-1 exists as a disulphide-linked homotrimer that functions to enhance insulin-stimulated glucose uptake and is also thought to participate in host defence against microorganisms. Serum levels of omentin are negatively correlated with obesity, suggesting a role in diabetes. More recently, omentin has been shown to interact with glycans on pathogenic bacteria.
- Immunogen: Q8WWA0
- Immunogen UniProt ID: Q8WWA0
- Isotype: IgG
- Research area: Microbiology; Tissue-specific biology; Immunology; Metabolism
- For Research Use Only
Target Details
- Target: Omentin
- Target molecular weight: 120 kDa (trimer), 37 kDa (monomer)
- Target background: Monoclonal antibody which detects omentin, linked to diabetes. Background and Research Application Omentin (human intelectin-1) is a secreted glycoprotein involved in the innate immune system as well as enhancing insulin-stimulated glucose uptake. Highly expressed in small intestine and adipose tissue and present at lower levels in testis, heart, pancreas, colon and skeletal muscle, intelectin-1 exists as a disulphide-linked homotrimer that functions to enhance insulin-stimulated glucose uptake and is also thought to participate in host defence against microorganisms. Serum levels of omentin are negatively correlated with obesity, suggesting a role in diabetes. More recently, omentin has been shown to interact with glycans on pathogenic bacteria.
Application Details
- Application: IP ; WB
Handling
- Format: Liquid
- Storage buffer:
- Storage conditions:
- Shipping conditions: Shipping at 4ðC
Related Tools
References
- • Yang et al. 2006. Am J Physiol Endocrinol Metab. 290(6):E1253-61. PMID: 16531507.
- • Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action.