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Contributor Information

  • Institute University of Maryland

Tool Details

  • Tool name: Anti-Omentin [3G1B3]
  • Alternate names: Intelectin-1, ITLN1, hIntL-1
  • Tool type: Antibodies
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human ; Mouse ; Rat
  • Host: Mouse
  • Molecular weight of the target: 120 kDa (trimer), 37 kDa (monomer)
  • Application: IP ; WB
  • Description: Monoclonal antibody which detects omentin, linked to diabetes. Background and Research Application: Omentin (human intelectin-1) is a secreted glycoprotein involved in the innate immune system as well as enhancing insulin-stimulated glucose uptake. Highly expressed in small intestine and adipose tissue and present at lower levels in testis, heart, pancreas, colon and skeletal muscle, intelectin-1 exists as a disulphide-linked homotrimer that functions to enhance insulin-stimulated glucose uptake and is also thought to participate in host defence against microorganisms. Serum levels of omentin are negatively correlated with obesity, suggesting a role in diabetes. More recently, omentin has been shown to interact with glycans on pathogenic bacteria.
  • Immunogen: Q8WWA0
  • Immunogen UniProt ID: Q8WWA0
  • Isotype: IgG
  • Research area: Microbiology; Tissue-specific biology; Immunology; Metabolism

  • For Research Use Only

Target Details

  • Target: Omentin
  • Target molecular weight: 120 kDa (trimer), 37 kDa (monomer)
  • Target background: Monoclonal antibody which detects omentin, linked to diabetes. Background and Research Application Omentin (human intelectin-1) is a secreted glycoprotein involved in the innate immune system as well as enhancing insulin-stimulated glucose uptake. Highly expressed in small intestine and adipose tissue and present at lower levels in testis, heart, pancreas, colon and skeletal muscle, intelectin-1 exists as a disulphide-linked homotrimer that functions to enhance insulin-stimulated glucose uptake and is also thought to participate in host defence against microorganisms. Serum levels of omentin are negatively correlated with obesity, suggesting a role in diabetes. More recently, omentin has been shown to interact with glycans on pathogenic bacteria.

Application Details

  • Application: IP ; WB

Handling

  • Format: Liquid
  • Storage buffer:
  • Storage conditions:
  • Shipping conditions: Shipping at 4°C

Documentation

References

  •   Yang et al. 2006. Am J Physiol Endocrinol Metab. 290(6):E1253-61. PMID: 16531507.
  •   Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action.