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Contributor Information

  • Name Pavel Kovarik
  • Institute University of Vienna

Tool Details

  • Tool name: Anti-TTP
  • Alternate names: TTP, ZFP36 Ring Finger Protein, Growth Factor-Inducible Nuclear Protein NUP475 G/G1 Switch Regulatory Protein 24, RNF162A, Zfp-36, NUP475, GS24, TIS11
  • Tool type: Antibodies
  • Tool sub-type: Primary Antibody
  • Class: Polyclonal
  • Conjugate: Unconjugated
  • Reactivity: Human ; Mouse
  • Host: Rabbit
  • Cancer type: Blood cancer
  • Molecular weight of the target: 36 kDa
  • Application: IP ; WB
  • Description: Members of the tristetraprolin (TTP) family of RNA binding proteins can bind to adenine/uridine-rich elements (AREs) in the 3’-untranslated regions (3’UTRs) of specific mRNAs, and then promote their turnover. For example, TTP is a component of a negative feedback loop that interferes with TNF-alpha production by destabilizing its mRNA. TTP has been shown to interact with 14-3-3 protein family members, such as YWHAH, and with NUP214, a member of the nuclear pore complex. Mice deficient in TTP develop a complex syndrome of inflammatory diseases.
  • Immunogen: 34 C-terminal amino acids of TTP fused to GST
  • Research area: Cell signaling and signal transduction; Genetics; Immunology

  • For Research Use Only

Target Details

  • Target: Tristetraprolin
  • Target molecular weight: 36 kDa
  • Target background: Members of the tristetraprolin (TTP) family of RNA binding proteins can bind to adenine/uridine-rich elements (AREs) in the 3'-untranslated regions (3'UTRs) of specific mRNAs, and then promote their turnover. For example, TTP is a component of a negative feedback loop that interferes with TNF-alpha production by destabilizing its mRNA. TTP has been shown to interact with 14-3-3 protein family members, such as YWHAH, and with NUP214, a member of the nuclear pore complex. Mice deficient in TTP develop a complex syndrome of inflammatory diseases.

Application Details

  • Application: IP ; WB

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Sedlyarov et al. 2016. Mol Syst Biol. 12(5):868. PMID: 27178967.
  • •  Tristetraprolin binding site atlas in the macrophage transcriptome reveals a switch for inflammationresolution.
  • •  Kratochvill et al. 2011. Mol Syst Biol. 7:560. PMID: 22186734.
  • •  Tristetraprolin-driven regulatory circuit controls quality and timing of mRNA decay in inflammation.
  • •  Schaljo et al. 2009. J Immunol. 183(2):1197-206. PMID: 19542371.
  • •  Tristetraprolin is required for full anti-inflammatory response of murine macrophages to IL-10.