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Contributor Information

  • Name Royal McGraw
  • Institute University of Georgia

Tool Details

  • Tool name: Anti-Tumor Necrosis Factor (TNF-a) [12F6]
  • Alternate names: TNF-?
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Horse
  • Host: Mouse
  • Application: ELISA ; IP ; WB
  • Description: Tumor necrosis factor is a cell signaling protein or cytokine that is involved in inflammation, and specifically one of the proteins in the acute phase reaction. TNF is produced mainly by macrophages but other white cells too. Some of its roles are to induce fever, apoptotic cell death, inhibit tumorigenesis and inflammation. Diseases associated with dysregulation of TNF production include inflammatory bowel disease (IBD), Psoriasis, Alzheimer's and cancer.
  • Immunogen: Protein
  • Isotype: IgG2b
  • Research area: Apoptosis and autophagy; Cell signaling and signal transduction

  • For Research Use Only

Target Details

  • Target: Tumor Necrosis Factor- alpha
  • Target background: Tumor necrosis factor is a cell signaling protein or cytokine that is involved in inflammation, and specifically one of the proteins in the acute phase reaction. TNF is produced mainly by macrophages but other white cells too. Some of its roles are to induce fever, apoptotic cell death, inhibit tumorigenesis and inflammation. Diseases associated with dysregulation of TNF production include inflammatory bowel disease (IBD), Psoriasis, Alzheimer's and cancer.

Application Details

  • Application: ELISA ; IP ; WB

Handling

  • Format: Liquid
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Su et al. 1992. Hybridoma. 11(6):715-27. PMID: 1284121.
  • •  Equine tumor necrosis factor alpha: cloning and expression in Escherichia coli, generation of monoclonal antibodies, and development of a sensitive enzyme-linked immunosorbent assay.