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Contributor Information

  • Name Laura Soucek
  • Institute Vall D'Hebron Institute Of Oncology (VHIO)
  • Primary citation Soucek et al. 2004. Cell Death Differ. 11(9):1038-45. PMID: 15143346.

Tool Details

  • Tool name: Anti-Omomyc [21-1-3]
  • Clone: [21-1-3]
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: ELISA ; IHC ; IF ; WB
  • Description: Monoclonal antibody specific for Omomyc, capable of suppressing Myc-induced oncogenesis. Omomyc is a dominant-negative allele of the proto-oncogene Myc (c-Myc). Omomyc is a mutant bHLHZip domain that sequesters Myc in complexes that are unable to bind to the E box recognition element and activate transcription but remain competent for transcriptional repression. Expression of Omomyc can induce rapid tumour regression in mouse models with little toxicity for normal tissues, acting as a suppressor of Myc-induced oncogenesis.
  • Isotype: IgG2a kappa
  • Research area: Apoptosis and autophagy; Cancer; Cell biology; Genetics

  • For Research Use Only

Target Details

  • Target: Omomyc
  • Target background: Monoclonal antibody specific for Omomyc, capable of suppressing Myc-induced oncogenesis. Omomyc is a dominant-negative allele of the proto-oncogene Myc (c-Myc). Omomyc is a mutant bHLHZip domain that sequesters Myc in complexes that are unable to bind to the E box recognition element and activate transcription but remain competent for transcriptional repression. Expression of Omomyc can induce rapid tumour regression in mouse models with little toxicity for normal tissues, acting as a suppressor of Myc-induced oncogenesis.

Application Details

  • Application: ELISA ; IHC ; IF ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: Store at -20°C frozen. Avoid repeated freeze / thaw cycles
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  MassĂł-VallĂŠs D et al. 2022. Cancer Res Commun. 2(2):110-130. PMID: 36860495.
  • •  Fiorentino et al. 2016. Oncotarget. 7(21):31014-28. PMID: 27105536.
  • •  Soucek et al. 2013. Genes Dev. 27(5):504-13. PMID: 23475959.
  • •  Soucek et al. 2004. Cell Death Differ. 11(9):1038-45. PMID: 15143346.