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Contributor Information

  • Institute BioServ UK Ltd

Tool Details

  • Tool name: Anti-Adiponectin [399R]
  • Alternate names: Adiponectin, 3 kDa adipocyte complement-related protein, Adipocyte complement-related 3 kDa protein, ACRP3, Adipose most abundant gene transcript 1 protein, apM-1, Gelatin-binding protein, ADIPOQ, ACDC, ACRP3, APM1, GBP28
  • Clone: 399R
  • Tool type: Antibodies
  • Tool sub-type: Primary Antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: ELISA
  • Strain: Balb/c
  • Description: Adiponectin plays an important role in pathogenesis and amplification of insulin-resistant states in humans, where levels are reduced in patients with type-2 diabetes and obesity. (Hotta K, et al.) Clone 399R is used to detect plasma adiponectin concentrations. Clone 399R is also used in a combination ELISA with clone 32F8, acting as the capture antibody.
  • Immunogen: Synthetic peptide corresponding to the tail region of the Adiponectin molecule
  • Isotype: IgG1
  • Research area: Tissue-specific biology; Metabolism
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: Adiponectin
  • Target background: Adiponectin plays an important role in pathogenesis and amplification of insulin-resistant states in humans, where levels are reduced in patients with type-2 diabetes and obesity. (Hotta K, et al.) Clone 399R is used to detect plasma adiponectin concentrations. Clone 399R is also used in a combination ELISA with clone 32F8, acting as the capture antibody.

Application Details

  • Application: ELISA

Handling

  • Format: Liquid
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Hazell, M.J. (2009) Development and Clinical Applications of Immunoassays for Human Adiponectin. Thesis. Oxford Brookes University
  • •  Miller et al. 2011. Am J Physiol Endocrinol Metab. 301(4):E659-67. PMID: 21750269.
  • •  Secretion of adipokines by human adipose tissue in vivo: partitioning between capillary and lymphatic transport.
  • •  Kiewiet et al. 2011. J Endocrinol Invest. 34(6):434-8. PMID: 20959720.
  • •  Acute effects of acylated and unacylated ghrelin on total and high molecular weight adiponectin inmorbidly obese subjects.
  • •  Sodi et al. 2009. Clin Biochem. 42(13-14):1375-80. PMID: 19523465.
  • •  The circulating concentration and ratio of total and high molecular weight adiponectin in post-menopausal women with and without osteoporosis and its association with body mass index and biochemical markers of bone metabolism.
  • •  Barber et al. 2008. J Clin Endocrinol Metab. 93(7):2859-65. PMID: 18445670.
  • •  Serum levels of retinol-binding protein 4 and adiponectin in women with polycystic ovary syndrome: associations with visceral fat but no evidence for fat mass-independent effects on pathogenesis in this condition.
  • •  Hotta et al. 2000. Arterioscler Thromb Vasc Biol. 20(6):1595-9. PMID: 10845877.
  • •  Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients.