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Contributor Information

  • Institute BioServ UK Ltd

Tool Details

  • Tool name: Anti-Myelin Basic Protein (region 36-50) [MBP14]
  • Alternate names: Myelin basic protein, MBP, 2 kDa microtubule-stabilizing protein, Myelin A1 protein
  • Clone: MBP14
  • Tool type: Antibodies
  • Tool sub-type: Primary Antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Bovine ; Chicken ; Horse ; Human
  • Host: Rat
  • Cancer type: Neurological cancer
  • Molecular weight of the target: 13-21 kDa
  • Application: ELISA ; IHC ; IF ; WB
  • Description: Myelin Basic Protein (MBP) is involved in the process of myelination of nerves in the nervous system. MBP Clone 14 recognizes an epitope in the 36-50 region of MBP, useful in clinical diagnosis to detect MBP levels or myelination in human MBP.
  • Immunogen: Reacts with human MBP, recognizing epitopes in the 36-50 amino acid region (GILDSIGRFFGGDRG)
  • Isotype: IgG2b
  • Research area: Cell biology; Immunology; Neurobiology
  • Myeloma used: NS0

  • For Research Use Only

Target Details

  • Target: Myelin Basic Protein (region 36-50)
  • Target molecular weight: 13-21 kDa
  • Target background: Myelin Basic Protein (MBP) is involved in the process of myelination of nerves in the nervous system. MBP Clone 14 recognizes an epitope in the 36-50 region of MBP, useful in clinical diagnosis to detect MBP levels or myelination in human MBP.

Application Details

  • Application: ELISA ; IHC ; IF ; WB

Handling

  • Format: Liquid
  • Shipping conditions: Shipping at 4°C

Documentation

References

  •   Friess et al. 2016. Cell Calcium. 60(5):322-330. PMID: 27417499.
  •   Intracellular ion signaling influences myelin basic protein synthesis in oligodendrocyte precursor cells.
  •   Jackson et al. 2004. Eur J Neurosci. 20(9):2267-75. PMID: 15525268.
  •   Cannabinoid-mediated neuroprotection following interferon-gamma treatment in a three-dimensional mouse brain aggregate cell culture.
  •   Matsuo et al. 1997. Am J Pathol. 150(4):1253-66. PMID: 9094982.
  •   Unmasking of an unusual myelin basic protein epitope during the process of myelin degeneration in humans: a potential mechanism for the generation of autoantigens.
  •   Groome et al. 1988. J Neuroimmunol. 19(4):305-15. PMID: 2459156.
  •   New monoclonal antibodies reactive with defined sequential epitopes in human myelin basic protein.
  •   Glynn et al. 1987. J Neurochem. 48(3):752-9. PMID: 2433395.
  •   Basic protein dissociating from myelin membranes at physiological ionic strength and pH is cleaved into three major fragments.