ANTIBODIES

Contributor Information
- Institute BioServ UK Ltd
Tool Details
- Tool name: Anti-Myelin Basic Protein (region 36-50) [MBP14]
- Alternate names: Myelin basic protein, MBP, 2 kDa microtubule-stabilizing protein, Myelin A1 protein
- Clone: MBP14
- Tool type: Antibodies
- Tool sub-type: Primary Antibody
- Class: Monoclonal
- Conjugate: Unconjugated
- Reactivity: Bovine ; Chicken ; Horse ; Human
- Host: Rat
- Cancer type: Neurological cancer
- Molecular weight of the target: 13-21 kDa
- Application: ELISA ; IHC ; IF ; WB
- Description: Myelin Basic Protein (MBP) is involved in the process of myelination of nerves in the nervous system. MBP Clone 14 recognizes an epitope in the 36-50 region of MBP, useful in clinical diagnosis to detect MBP levels or myelination in human MBP.
- Immunogen: Reacts with human MBP, recognizing epitopes in the 36-50 amino acid region (GILDSIGRFFGGDRG)
- Isotype: IgG2b
- Research area: Cell biology; Immunology; Neurobiology
- Myeloma used: NS0
- For Research Use Only
Target Details
- Target: Myelin Basic Protein (region 36-50)
- Target molecular weight: 13-21 kDa
- Target background: Myelin Basic Protein (MBP) is involved in the process of myelination of nerves in the nervous system. MBP Clone 14 recognizes an epitope in the 36-50 region of MBP, useful in clinical diagnosis to detect MBP levels or myelination in human MBP.
Application Details
- Application: ELISA ; IHC ; IF ; WB
Handling
- Format: Liquid
- Shipping conditions: Shipping at 4ðC
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References
- • Friess et al. 2016. Cell Calcium. 60(5):322-330. PMID: 27417499.
- • Intracellular ion signaling influences myelin basic protein synthesis in oligodendrocyte precursor cells.
- • Jackson et al. 2004. Eur J Neurosci. 20(9):2267-75. PMID: 15525268.
- • Cannabinoid-mediated neuroprotection following interferon-gamma treatment in a three-dimensional mouse brain aggregate cell culture.
- • Matsuo et al. 1997. Am J Pathol. 150(4):1253-66. PMID: 9094982.
- • Unmasking of an unusual myelin basic protein epitope during the process of myelin degeneration in humans: a potential mechanism for the generation of autoantigens.
- • Groome et al. 1988. J Neuroimmunol. 19(4):305-15. PMID: 2459156.
- • New monoclonal antibodies reactive with defined sequential epitopes in human myelin basic protein.
- • Glynn et al. 1987. J Neurochem. 48(3):752-9. PMID: 2433395.
- • Basic protein dissociating from myelin membranes at physiological ionic strength and pH is cleaved into three major fragments.