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Contributor Information

  • Institute BioServ UK Ltd

Tool Details

  • Tool name: Anti-Estrogen Receptor Beta5 [PPG5/25]
  • Alternate names: Estrogen receptor beta, ER-beta, Nuclear receptor subfamily 3 group A member 2
  • Clone: PPG5/25
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Cancer type: Gynaecologic cancer; Breast cancer;
  • Application: IHC ; IF ; WB
  • Description: Estrogen receptors are commonly over-expressed in cancers. Clone PPG5/25 recognizes Estrogen Receptor Beta (ERÎ?) 5 and is useful in determining the expression of ERÎ?5 in cancer cells, mainly via immunohistochemistry.
  • Immunogen: Tuberculin conjugated peptide that recognizes C terminus of ER?5 at sequence LLSHVRHARYAP
  • Isotype: IgG1
  • Research area: Cancer; Immunology; Neurobiology
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: Estrogen Receptor ? 5
  • Target background: Estrogen receptors are commonly over-expressed in cancers. Clone PPG5/25 recognizes Estrogen Receptor Beta (ER?) 5 and is useful in determining the expression of ER?5 in cancer cells, mainly via immunohistochemistry.

Application Details

  • Application: IHC ; IF ; WB

Handling

  • Format: Liquid
  • Storage conditions: -80°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Zannoni et al. 2016. Histopathology. 68(4):541-8. PMID: 26132417.
  • •  Li et al. 2015. Oncol Lett. 10(4):2341-2346. PMID: 26622848.
  • •  Sexual dimorphism in medulloblastoma features.
  • •  Cytoplasm estrogen receptor ?5 as an improved prognostic factor in thymoma and thymic carcinoma progression.
  • •  Gender effect in experimental models of human medulloblastoma: does the estrogen receptor ? signaling play a role?
  • •  Ciucci et al. 2014. PLoS One. 9(7):e101623. PMID: 25000562.
  • •  Collins et al. 2009. BMC Cancer. 9:330. PMID: 19758455.
  • •  Expression of oestrogen receptors, ERalpha, ERbeta, and ERbeta variants, in endometrial cancers and evidence that prostaglandin F may play a role in regulating expression of ERalpha.
  • •  Wong et al. 2005. J Pathol. 207(1):53-60. PMID: 15954165.
  • •  ERbeta isoform expression in colorectal carcinoma: an in vivo and in vitro study of clinicopathological and molecular correlates.