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Contributor Information

  • Institute BioServ UK Ltd

Tool Details

  • Tool name: Anti-Estrogen Receptor Beta2 [57/3]
  • Alternate names: Estrogen receptor beta, ER-beta, Nuclear receptor subfamily 3 group A member 2
  • Clone: 57/3
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Cancer type: Gynaecologic cancer; Breast cancer;
  • Molecular weight of the target: 53 kDa
  • Application: IHC ; IF ; WB
  • Strain: Balb/c
  • Description: Estrogen receptors are commonly over-expressed in cancers. Clone 57/3 recognizes Estrogen Receptor Beta (ERÎ?) 2 and is useful in determining the expression of ERÎ?2 in cancer cells via various analysis methods.
  • Immunogen: Recognizes ER?2 isomer at sequence CGMKMETLLPEATMEQ
  • Isotype: IgG1
  • Research area: Cancer; Immunology
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: Estrogen Receptor ? 2
  • Target molecular weight: 53 kDa
  • Target background: Estrogen receptors are commonly over-expressed in cancers. Clone 57/3 recognizes Estrogen Receptor Beta (ER?) 2 and is useful in determining the expression of ER?2 in cancer cells via various analysis methods.

Application Details

  • Application: IHC ; IF ; WB

Handling

  • Format: Liquid
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Buttarelli et al. 2017. Gynecol Oncol. 145(2):352-360. PMID: 28228232.
  • •  Hormone receptor expression profile of low-grade serous ovarian cancers.
  • •  Zannoni et al. 2016. Histopathology. 68(4):541-8. PMID: 26132417.
  • •  Sexual dimorphism in medulloblastoma features.
  • •  Gender effect in experimental models of human medulloblastoma: does the estrogen receptor ? signaling play a role?
  • •  Ciucci et al. 2014. PLoS One. 9(7):e101623. PMID: 25000562.
  • •  Collins et al. 2009. BMC Cancer. 9:330. PMID: 19758455.
  • •  Expression of oestrogen receptors, ERalpha, ERbeta, and ERbeta variants, in endometrial cancers and evidence that prostaglandin F may play a role in regulating expression of ERalpha.
  • •  Carpino et al. 2007. Eur J Endocrinol. 157(2):239-44. PMID: 17656605.
  • •  Detection of aromatase and estrogen receptors (ERalpha, ERbeta1, ERbeta2) in human Leydig cell tumor.
  • •  Skliris et al. 2006. Br J Cancer. 95(5):616-26. PMID: 16880783.
  • •  Expression of oestrogen receptor-beta in oestrogen receptor-alpha negative human breast tumours.
  • •  Wong et al. 2005. J Pathol. 207(1):53-60. PMID: 15954165.
  • •  ERbeta isoform expression in colorectal carcinoma: an in vivo and in vitro study of clinicopathological and molecular correlates.
  • •  Sierens et al. 2004. J Mol Endocrinol. 32(3):703-18. PMID: 15171710.
  • •  Cloning of oestrogen receptor beta from Old and New World primates: identification of splice variants and Fn analysis.
  • •  Critchley et al. 2002. J Clin Endocrinol Metab. 87(11):5265-73. PMID: 12414901.
  • •  Wild-type estrogen receptor (ERbeta1) and the splice variant (ERbetacx/beta2) are both expressed within the human endometrium throughout the normal menstrual cycle.
  • •  Ogawa et al. 1998. Nucleic Acids Res. 26(15):3505-12. PMID: 9671811.
  • •  Molecular cloning and characterization of human estrogen receptor betacx: a potential inhibitor ofestrogen action in human.