ANTIBODIES

Contributor Information
- Name Margaret Goodall
- Institute University of Birmingham
Tool Details
- Tool name: Anti-CD11a [BU17]
- Alternate names: Integrin alpha L; lymphocyte function-associated antigen 1 alpha polypeptide; ITGAL; cell differentiation 11a
- Tool type: Antibodies
- Tool sub-type: Primary antibody
- Class: Monoclonal
- Conjugate: Unconjugated
- Reactivity: Human
- Host: Mouse
- Application: FACS
- Description: CD11A encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of alpha and beta chains. This L-domain containing alpha integrin combines with the beta 2 chain to form the integrin lymphocyte function-associated antigen-1 expressed on all leukocytes and this plays a central role in leukocyte intercellular adhesion through interactions with its ligands.
- Immunogen: Waldenstroms macroglobulinaemia a late B cell line with surface and secreted IgM Kappa
- Isotype: IgG1
- Research area: Cell signaling and signal transduction
- For Research Use Only
Target Details
- Target: CD11a
- Target background: CD11A encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of alpha and beta chains. This L-domain containing alpha integrin combines with the beta 2 chain to form the integrin lymphocyte function-associated antigen-1 expressed on all leukocytes and this plays a central role in leukocyte intercellular adhesion through interactions with its ligands.
Application Details
- Application: FACS
Handling
- Format: Liquid
- Concentration: 0.9-1.1 mg/ml
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15ðC to -25ðC
- Shipping conditions: Shipping at 4ðC
References
- • Rezzonico et al. 2001. Blood. 97(10):2932-40. PMID: 11342414.
- • Ligation of CD11b and CD11c beta(2) integrins by antibodies or soluble CD23 induces macrophage inflammatory protein 1alpha (MIP-1alpha) and MIP-1beta production in primary human monocytes through a pathway dependent on nuclear factor-kappaB.
- • Baker et al. 1998. Blood. 92(8):2830-43. PMID: 9763568.
- • Prolonged phenotypic, Fn, and molecular change in group I Burkitt lymphoma cells on short-term exposure to CD40 ligand.