ANTIBODIES
Contributor Information
- Name
- Institute Clonegene LLC
Tool Details
- Tool name: Anti-EGFR [225]
- Alternate names: EGFR, ErbB-1, HER1
- Clone: 225
- Tool type: Antibodies
- Tool sub-type: Primary antibody
- Class: Monoclonal
- Conjugate: Unconjugated
- Reactivity: Human
- Host: Mouse
- Description: Mutations that lead to EGFR overexpression (known as upregulation) or overactivity have been associated with a number of cancers, including squamous-cell carcinoma of the lung, anal cancers, glioblastoma and epithelial tumors of the head and neck. These somatic mutations involving EGFR lead to its constant activation, which produces uncontrolled cell division. In glioblastoma a more or less specific mutation of EGFR, called EGFRvIII is often observed. Mutations, amplifications or misregulations of EGFR or family members are implicated in about 30% of all epithelial cancers. Monoclonal 225 is a classic reagent in tumor therapy with more than 100 published references. The human/mouse chimeric antibody known as Cetuximab was derived from this monoclonal antibody.
- Isotype: IgG1
- Research area: Cell signaling and signal transduction
- For Research Use Only
Target Details
- Target: Epidermal Growth Factor Receptor
- Target background: Mutations that lead to EGFR overexpression (known as upregulation) or overactivity have been associated with a number of cancers, including squamous-cell carcinoma of the lung, anal cancers, glioblastoma and epithelial tumors of the head and neck. These somatic mutations involving EGFR lead to its constant activation, which produces uncontrolled cell division. In glioblastoma a more or less specific mutation of EGFR, called EGFRvIII is often observed. Mutations, amplifications or misregulations of EGFR or family members are implicated in about 30% of all epithelial cancers. Monoclonal 225 is a classic reagent in tumor therapy with more than 100 published references. The human/mouse chimeric antibody known as Cetuximab was derived from this monoclonal antibody.
Application Details
Handling
- Format: Liquid
- Shipping conditions: Shipping at 4Ă°C
Documentation
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