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Contributor Information

  • Name Dallas Swallow
  • Institute University College London (UCL)

Tool Details

  • Tool name: Anti-Sucrase-Isomaltase [mglu1]
  • Alternate names: Sucrase-isomaltase, CSID, Oligosaccharide alpha 1, 6 glucosidase, AKA: Mglu1 - [3G51/2E1]
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: ELISA ; IP
  • Strain: Balb/c
  • Description: Sucrase-isomaltase is a glucosidase enzyme and type II transmembrane glycoprotein located in the apical brush border membrane of small intestinal enterocytes. Sucrase-isomaltase digests dietary sucrose, maltose and isomaltose, which produces monosaccharides which can be taken up into the enterocytes and ultimately used as a source of energy. Defects in sucrase-isomaltase are the cause of the disease; congenital sucrase-isomaltase deficiency also known as disaccharide intolerance I. This an autosomal recessive intestinal disorder that is clinically characterized by abdominal pain, fermentative diarrhea and cramping.
  • Immunogen: Normal human jejunal epithelial brush border-enriched membranes from a non-secretor and blood group O
  • Isotype: IgG1
  • Research area: Cancer; Cell signaling and signal transduction; Immunology; Metabolism
  • Myeloma used: P3/NS1/1-Ag4.1

  • For Research Use Only

Target Details

  • Target: Sucrase-isomaltase
  • Target background: Sucrase-isomaltase is a glucosidase enzyme and type II transmembrane glycoprotein located in the apical brush border membrane of small intestinal enterocytes. Sucrase-isomaltase digests dietary sucrose, maltose and isomaltose, which produces monosaccharides which can be taken up into the enterocytes and ultimately used as a source of energy. Defects in sucrase-isomaltase are the cause of the disease; congenital sucrase-isomaltase deficiency also known as disaccharide intolerance I. This an autosomal recessive intestinal disorder that is clinically characterized by abdominal pain, fermentative diarrhea and cramping.

Application Details

  • Application: ELISA ; IP

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Green et al. 1988. Subcell Biochem. 12:119-53. PMID: 3043765.
  • •  Expression of the ABH, Lewis, and related antigens on the glycoproteins of the human jejunal brush border.