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Contributor Information

  • Institute A*STAR Accelerate Technologies Pte Ltd

Tool Details

  • Tool name: Anti-C-kit (CD117) [1C8]
  • Alternate names: C Kit antibody, c-Kit antibody, CD117 antibody
  • Clone: 1C8
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: FACS ; WB
  • Strain: Balb/c
  • Description: C-kit, also known as CD117, is expressed on the surface of hematopoietic stem cells. C-kit is a receptor tyrosine kinase that is overexpressed in > 70% of gastrointestinal stromal tumors (GISTs).
  • Immunogen: GST-fusion protein containing 315-519 residues of human c-kit. c-kit. This region is in the extracellular domain of c-kit.
  • Isotype: IgG1
  • Research area: Cancer; Immunology
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: C-kit
  • Target background: C-kit, also known as CD117, is expressed on the surface of hematopoietic stem cells. C-kit is a receptor tyrosine kinase that is overexpressed in > 70% of gastrointestinal stromal tumors (GISTs).

Application Details

  • Application: FACS ; WB

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Bellone et al. 2001. Cancer Res. 61(5):2200-6. PMID: 11280787.
  • •  Aberrant activation of c-kit protects colon carcinoma cells against apoptosis and enhances their invasive potential.