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Contributor Information

  • Name Mike Price
  • Institute University of Nottingham

Tool Details

  • Tool name: Anti-MUC2 [996/1]
  • Alternate names: MUC-2; SMUC; MLP , Mucin2
  • Clone: 996/1
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Cancer type: Digestive / Gastrointestinal cancer
  • Molecular weight of the target: 540 kDa
  • Application: FACS ; IHC ; WB
  • Description: Mucin 2/MUC2 is a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight.
  • Immunogen: MUC-2 tandem repeat peptide
  • Isotype: IgG1
  • Research area: Cancer; Cell biology; Genetics
  • Myeloma used: NS0

  • For Research Use Only

Target Details

  • Target: MUC2
  • Target molecular weight: 540 kDa
  • Target background: Mucin 2/MUC2 is a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight.

Application Details

  • Application: FACS ; IHC ; WB

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Wang et al. 2015. JPEN J Parenter Enteral Nutr. 39(6):688-97. PMID: 24836948.
  • •  Forbester et al. 2015. Infect Immun. 83(7):2926-34. PMID: 25964470.
  • •  Interaction of Salmonella enterica Serovar Typhimurium with Intestinal Organoids Derived from Human Induced Pluripotent Stem Cells.
  • •  Glutamine Improves Innate Immunity and Prevents Bacterial Enteroinvasion During Parenteral Nutrition.
  • •  Luo et al. 2014. Infect Immun. 82(2):509-21. PMID: 24478067.
  • •  He et al. 2013. PLoS One. 8(12):e79769. PMID: 24324582.
  • •  High MUC2 expression in ovarian cancer is inversely associated with the M1/M2 ratio of tumor-associated macrophages and patient survival time.
  • •  Enterotoxigenic Escherichia coli secretes a highly conserved mucin-degrading metalloprotease to effectively engage intestinal epithelial cells.
  • •  Pierre et al. 2013. JPEN J Parenter Enteral Nutr. 37(3):401-9. PMID: 23064255.
  • •  Cranberry proanthocyanidins improve the gut mucous layer morphology and function in mice receiving elemental enteral nutrition.
  • •  Algamas-Dimantov et al. 2012. J Lipid Res. 53(6):1056-70. PMID: 22357704.
  • •  Amelioration of diabesity-induced colorectal ontogenesis by omega-3 fatty acids in mice.
  • •  Vermeulen et al. 2010. Nat Cell Biol. 12(5):468-76. PMID: 20418870.
  • •  Wnt activity defines colon cancer stem cells and is regulated by the microenvironment.
  • •  Guilmeau et al. 2010. Oncogene. 29(7):992-1002. PMID: 19935714.
  • •  Heterogeneity of Jagged1 expression in human and mouse intestinal tumors: implications for targeting Notch signaling.
  • •  Durrant et al. 1994. Eur J Cancer. 30A(3):355-63. PMID: 8204359.
  • •  Production of monoclonal antibodies recognising the peptide core of MUC2 intestinal mucin.