ANTIBODIES
Contributor Information
- Name Richard Marais
- Institute The Institute of Cancer Research
Tool Details
- Tool name: Anti-KSR [MINT/1/14]
- Alternate names: RSU2; KSR
- Clone: MINT/1/14
- Tool type: Antibodies
- Tool sub-type: Primary antibody
- Class: Monoclonal
- Conjugate: Unconjugated
- Reactivity: Human ; Mouse ; Rat
- Host: Rat
- Molecular weight of the target: 140 kDa
- Application: IHC ; WB
- Description: Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity. In unstimulated cells, where the phosphorylated form is bound to a 14-3- 3 protein, sequestration in the cytoplasm occurs. Following growth factor treatment, the protein is free for membrane translocation, and it moves from the cytoplasm to the cell periphery.
- Immunogen: Recombinant human KSR protein
- Isotype: IgG2a
- Research area: Cancer; Cell signaling and signal transduction
- For Research Use Only
Target Details
- Target: KSR
- Target molecular weight: 140 kDa
- Target background: Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity. In unstimulated cells, where the phosphorylated form is bound to a 14-3- 3 protein, sequestration in the cytoplasm occurs. Following growth factor treatment, the protein is free for membrane translocation, and it moves from the cytoplasm to the cell periphery.
Application Details
- Application: IHC ; WB
Handling
- Format: Liquid
- Concentration: 0.9-1.1 mg/ml
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15Ă°C to -25Ă°C
- Shipping conditions: Shipping at 4Ă°C
Documentation
.svg)
Unit size: 
.svg)
.svg)
