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Anti-IL21 [V28P5G1*C4]

Cat. #153375

Tool name: Anti-IL21 [V28P5G1*C4]
Alternate names: IL 21 antibody, Interleukin 21 antibody, Interleukin21 antibody
Clone: V28P5G1*C4
Tool type: Antibodies
Tool sub-type: Primary antibody
Class: Monoclonal
Conjugate: Unconjugated
Reactivity: Salmon ; Rainbow Trout
Host: Mouse
Application: ELISA ; IHC ; WB
Strain: Balb/c
Description: IL21 is a member of the type I cytokine family, which includes IL2 and IL15. IL21 signals through the common gamma-chain and a unique IL21 receptor. The IL21 receptor is expressed in cells lymphoid-lineage and regulates the proliferation and differentiation of T and B lymphocytes. Studies suggest that IL21 is a key component of CD4 T cell help that is required for maintaining the CD8+ T cell responses and inducing B cell antibody response. IL21 also promotes the development of Th17 and Tfh cells, modulates the cytotoxic activity and survival of NK and CD8+ T cells, and suppresses the maturation of dendritic cells. It is also implicated in the development of autoimmune disease and has antitumor activity.
Immunogen: Ovalbumin-conjugated synthetic peptide- LLQKAISRLA
Isotype: IgG
Research area: Cancer; Immunology
Myeloma used: P3X63Ag8.653

Target: Interleukin 21 (IL21)
Target background: IL21 is a member of the type I cytokine family, which includes IL2 and IL15. IL21 signals through the common gamma-chain and a unique IL21 receptor. The IL21 receptor is expressed in cells lymphoid-lineage and regulates the proliferation and differentiation of T and B lymphocytes. Studies suggest that IL21 is a key component of CD4 T cell help that is required for maintaining the CD8+ T cell responses and inducing B cell antibody response. IL21 also promotes the development of Th17 and Tfh cells, modulates the cytotoxic activity and survival of NK and CD8+ T cells, and suppresses the maturation of dendritic cells. It is also implicated in the development of autoimmune disease and has antitumor activity.

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