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Contributor Information

  • Name Mike Owen
  • Institute Cancer Research UK, London Research Institute: Lincoln's Inn Fields ; Absolute Antibody

Tool Details

  • Tool name: Anti-TCR CBeta1 [JOVI.1]rAb
  • Clone: rJOVI.1
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Recombinant
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: FACS ; IHC ; IF ; IP
  • Description: Recombinant antibody which aids investigation into T-cell mediated diseases. Background and Research Application The T cell receptor is expressed on all mature T cells. The T cell receptor is heterodimer of alpha/beta or gamma/delta chains, expressed on all mature T cells. TCR’s recognize antigen peptides bound to MHC molecules, providing the basis of antigen specific response by T cells. Genetic mutations involving the T cell receptor ? locus have been associated with T cell lymphomas. Recombinant version of the anti-JOVI.1 monoclonal antibody. JOVI.1 can be used for studies of T-cell mediated diseases, including autoimmunity and allergy. Antibody JOVI?1 recognised a determinant on the majority of TCRs, staining 50-75% of peripheral blood T cells and T cell lines expressing different V? regions.
  • Immunogen: Thymus, spleen and mesenteric lymph nodes isolated from a mouse transgenic for human Vb3 TcR.
  • Immunogen UniProt ID: P01850
  • Isotype: IgG2a
  • Research area: Cell biology; Immunology

  • For Research Use Only

Target Details

  • Target: TCR C?1
  • Target background: Recombinant antibody which aids investigation into T-cell mediated diseases. Background and Research Application The T cell receptor is expressed on all mature T cells. The T cell receptor is heterodimer of alpha/beta or gamma/delta chains, expressed on all mature T cells. TCR's recognize antigen peptides bound to MHC molecules, providing the basis of antigen specific response by T cells. Genetic mutations involving the T cell receptor ? locus have been associated with T cell lymphomas. Recombinant version of the anti-JOVI.1 monoclonal antibody. JOVI.1 can be used for studies of T-cell mediated diseases, including autoimmunity and allergy. Antibody JOVI1 recognised a determinant on the majority of TCRs, staining 50-75% of peripheral blood T cells and T cell lines expressing different V? regions.

Application Details

  • Application: FACS ; IHC ; IF ; IP

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS
  • Storage conditions: Store at -20°C frozen. Avoid repeated freeze / thaw cycles
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Original hybridoma first published in: Viney et al. 1992. Hybridoma. 11(6):701-13. PMID: 1284120.